{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:00:07Z","timestamp":1787065207248,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background and Objective<\/jats:italic>\n                    . There is a growing body of evidence for the efficacy of oleoylethanolamide (OEA) in patients with inflammatory disorders. The present randomized double\u2010blind placebo\u2010controlled study is aimed at evaluating the efficacy of OEA add\u2010on treatment in patients with acute ischemic stroke (AIS).\n                    <jats:italic>Methods<\/jats:italic>\n                    . Sixty patients with a mean age of 68.60 \u00b1 2.10 comprising 29 females (48.33%), who were admitted to an academic tertiary care facility within the first 12 hours poststroke symptoms onset or last known well (LKW), in case symptom onset time is not clear, were included in this study. AIS was confirmed based on a noncontrast head CT scan and also neurological symptoms. Patients were randomly and blindly assigned to OEA of 300\u2009mg\/day (\n                    <jats:italic>n<\/jats:italic>\n                    = 20) or 600\u2009mg\/day (\n                    <jats:italic>n<\/jats:italic>\n                    = 20) or placebo (\n                    <jats:italic>n<\/jats:italic>\n                    = 20) in addition to the standard AIS treatment for three days. A blood sample was drawn at 12 hours from symptoms onset or LKW as the baseline followed by the second blood sample at 72 hours post symptoms onset or LKW. Blood samples were assessed for inflammatory and biochemical parameters, oxidative stress (OS) biomarkers, and lipid profile.\n                    <jats:italic>Results<\/jats:italic>\n                    . Compared to the baseline, there is a significant reduction in the urea, creatinine, triglyceride, high\u2010density lipoprotein, cholesterol, alanine transaminase, total antioxidant capacity, malondialdehyde (MDA), total thiol groups (TTG), interleukin\u20106 (IL\u20106), and C\u2010reactive protein levels on the follow\u2010up blood testing in the OEA (300\u2009mg\/day) group. In patients receiving OEA (600\u2009mg\/day) treatment, there was only a significant reduction in the MDA level comparing baseline with follow\u2010up blood testing. Also, the between\u2010group analysis revealed a statistically significant difference between patients receiving OEA (300\u2009mg\/day) and placebo in terms of IL\u20106 and TTG level reduction when comparing them between baseline and follow\u2010up blood testing.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . OEA in moderate dosage, 300\u2009mg\/day, add\u2010on to the standard stroke treatment improves short\u2010term inflammatory, OS, lipid, and biochemical parameters in patients with AIS. This effect might lead to a better long\u2010term neurological prognosis.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5721167","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:50:25Z","timestamp":1662684625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Effect of Oleoylethanolamide (OEA) Add\u2010On Treatment on Inflammatory, Oxidative Stress, Lipid, and Biochemical Parameters in the Acute Ischemic Stroke Patients: Randomized Double\u2010Blind Placebo\u2010Controlled Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-226X","authenticated-orcid":false,"given":"Mohammadmahdi","family":"Sabahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara 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