{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:58:17Z","timestamp":1775815097408,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of AYUSH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:p>Objectives. Abnormal vaginal discharge (Sayalan al-Rahim) is a common public health problem that significantly disrupts the health-related quality of life (HRQoL). Syndromic management infers the concurrent treatment of two or more infections. Hence, a comparative, single-blind study was planned to determine the efficacy of Acacia (Acacia nilotica Linn.) pod\u2019s sitz bath (Abzan) plus vaginal pessary (Farzaja) vs. placebo in abnormal vaginal discharge syndromic management, its associated symptoms, and women\u2019s HRQoL. Methods. Diagnosed patients (n\u2009=\u200966) were randomly divided into Acacia (n\u2009=\u200933) and placebo (n\u2009=\u200933) group. Acacia group received Sitz bath with Acacia pod powder (30g) solution followed by vaginal cotton pessary (5\u2009ml of the same solution) once daily for 10\u2009days. The placebo group received palm sugar powder (30g) solution for Sitz bath plus vaginal cotton pessary same as the Acacia group. Primary outcomes included clinical cure assessed with VAS for symptoms and Modified McCormack Pain Scale (McPS) for pelvic tenderness. The secondary outcomes included were the EQ-5D-5\u2009L questionnaire, TSQM questionnaire, sachet count, and microbiological cure. Overall, therapeutic cure included clinical and microbiological cure after treatment. Results. The overall therapeutic cure for bacterial vaginosis, cervicitis, and uncomplicated pelvic inflammatory disease was 100% (n\u2009=\u20097\/7), 45.45% (n\u2009=\u200910\/22), and 71.42% (n\u2009=\u20095\/7), respectively, in the Acacia group, while in the placebo group none of the patients had responded. The VAS score for symptoms was significantly reduced in Acacia than in the placebo group. At each follow-up, the improvement in the EQ-5D-5\u2009L level of HRQoL was significantly higher in the Acacia group than in the placebo group. Conclusion. Acacia would be an effective and safe alternative in syndromic management of abnormal vaginal discharge, associated symptoms, and improved women\u2019s HRQoL. Trial registration. This trial was registered in the Clinical Trials Registry of Indian Trials Website and given the identification no. CTRI\/2018\/02\/012175 (dated: 27\/02\/2018).<\/jats:p>","DOI":"10.1155\/2022\/5769555","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T17:05:09Z","timestamp":1653498309000},"page":"1-11","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Acacia nilotica Linn. Pod\u2019s Sitz Bath plus Vaginal Pessary in Syndromic Management of Abnormal Vaginal Discharge: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-817X","authenticated-orcid":true,"given":"Rushda","family":"Saeedi","sequence":"first","affiliation":[{"name":"Department of Amraze Niswan wa Ilmul Qabalat, National Institute of Unani Medicine, Ministry of AYUSH, Government of India, Bengaluru 560091, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2099-1510","authenticated-orcid":true,"given":"Arshiya","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Amraze Niswan wa Ilmul Qabalat, National Institute of Unani Medicine, Ministry of AYUSH, Government of India, Bengaluru 560091, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-9631","authenticated-orcid":true,"given":"Khaleequr","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Ilmul Saidla, National Institute of Unani Medicine, Ministry of AYUSH, Government of India, Bengaluru 560091, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5307-9582","authenticated-orcid":true,"given":"Md","family":"Belal Bin Heyat","sequence":"additional","affiliation":[{"name":"IoT Research Center, College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China"},{"name":"International Institute of Information Technology, Hyderabad, Telangana 500032, India"},{"name":"Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW 2770, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-0565","authenticated-orcid":true,"given":"Mohammad Amjad","family":"Kamal","sequence":"additional","affiliation":[{"name":"Institute for Systems Genetics, Frontier Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia"},{"name":"Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Bangladesh"},{"name":"Enzymoics, Novel Global Community Educational Foundation, Hebersham, NSW 2770, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2171-9597","authenticated-orcid":true,"given":"Mumuni","family":"Ishawu","sequence":"additional","affiliation":[{"name":"Faculty of Business and Management Studies, Koforidua Technical University, Koforidua, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/1110-208X.206900","article-title":"Comparison of visual, clinical, and microbiological diagnosis of symptomatic vaginal discharge in the reproductive age group","volume":"34","author":"A. 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