{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:18:37Z","timestamp":1740140317793,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1A09083797"],"award-info":[{"award-number":["2018R1D1A1A09083797"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,5,14]]},"abstract":"<jats:p>Objective. Duchesnea indica has been reported for its anti-inflammatory properties. However, its efficacy in sepsis has yet to be reported. In this study, we studied the ability of Duchesnea indica extract (DIE) to rescue mice from septic shock and sepsis. Methods. In vitro studies included the measurement of secreted nitric oxide, cell viability, gene and protein expression via real-time polymerase chain reaction and western blot, and confocal microscopy in RAW 264.7 cells. In vivo studies include a model of septic shock and sepsis in BALB\/c mice induced by a lethal and sub-lethal dose of lipopolysaccharide (LPS). Results. DIE suppressed the expression of proinflammatory cytokines induced by LPS and prevented the translocation of NF\u03baB into the nucleus of RAW 264.7 cells. It also prevented reactive oxygen species damage induced by LPS in murine bone marrow-derived macrophages. Models of sepsis and septic shock were established in BALB\/c mice and DIE-rescued mice from septic shock. DIE also reversed the increase in tumor necrosis factor-\u03b1 and nitrite levels in the serum of mice induced with sepsis. DIE also prevented the translocation of NF\u03baB from the cytosol into the nucleus in murine lungs. Histopathological damage induced by sepsis was reversed in the testis, liver, and lungs of mice. Conclusion. In conclusion, DIE is a suitable candidate for development as a therapeutic agent for sepsis.<\/jats:p>","DOI":"10.1155\/2022\/5783867","type":"journal-article","created":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T06:20:12Z","timestamp":1652595612000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["Duchesnea indica Extract Ameliorates LPS-Induced Septic Shock in Mice"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-3048","authenticated-orcid":true,"given":"Yuan Yee","family":"Lee","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4705-4538","authenticated-orcid":true,"given":"Heung Joo","family":"Yuk","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-1895","authenticated-orcid":true,"given":"Evelyn","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi 46000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-8888","authenticated-orcid":true,"given":"Sung Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1711-0906","authenticated-orcid":true,"given":"Dong-Seon","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3379-4797","authenticated-orcid":true,"given":"Spandana Rajendra","family":"Kopalli","sequence":"additional","affiliation":[{"name":"Department of Integrative Bioscience and Biotechnology, Sejong University, Gwangjin-Gu, Seoul 05006, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-0499","authenticated-orcid":true,"given":"Jae-Wook","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, KIT, Konkuk University, Seoul 05029, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-1318","authenticated-orcid":true,"given":"Man Hee","family":"Rhee","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1001\/jama.2016.0287"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1111\/j.1445-2197.1992.tb07559.x"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1136\/bmj.2.6049.1418"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.3389\/fcimb.2020.00258"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1177\/2058739220926878"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1038\/nrdp.2016.45"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1074\/jbc.274.16.10689"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1016\/j.jgr.2017.05.005"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1124\/mol.117.111047"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1002\/tox.22420"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1016\/j.phymed.2019.152960"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1111\/jfbc.12899"},{"key":"13","article-title":"Characterisation of antioxidant, anti-inflammatory, and immunomodulatory activities of polysaccharides derived from Duchesnea indica (Andrews) Focke","volume":"27","author":"M. 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