{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:12:49Z","timestamp":1767168769108,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":271,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Funds for the Innovation Of Science and Technology","award":["2019Y9088"],"award-info":[{"award-number":["2019Y9088"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Traumatic tissue develops an uncontrolled inflammatory response that causes secondary damage to the injured tissue and other parts of the body. Therefore, preventing wound infection, reducing inflammatory response, and reducing secondary tissue damage are the keys to early treatment of tissue trauma. In the treatment of gingival soft tissue trauma, anti\u2010inflammatory and analgesic drugs are reasonably selected according to the condition, which can effectively reduce inflammation, and they help periodontal tissue regeneration and healing. However, there are few studies on the mechanism of anti\u2010inflammatory drugs in the early treatment of oral gingival mucosal soft tissue trauma, and the specific mechanism is unknown. Therefore, this paper explored the mechanism of anti\u2010inflammatory drugs in the early treatment of oral gingival mucosa and soft tissue trauma through experiments, which provided theoretical support for the clinical treatment of gingival mucosa and soft tissue trauma repair. In this paper, two anti\u2010inflammatory drugs, levofloxacin and metronidazole, were selected to measure their release properties\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Then, the white\u2010eared rabbits were treated with gingival wound treatment experiments, and the physiological characteristics, intratissue pressure, tissue partial pressure of oxygen, IL\u20106 content, and PGE2 content were determined at each postinjury period, and the mechanism of action of anti\u2010inflammatory drugs was determined. Research results have shown that anti\u2010inflammatory drugs can significantly inhibit the content of IL\u20106 and PGE2 in gingival soft tissue after injury, reduce the local inflammatory response, and accelerate tissue healing.\n                  <\/jats:p>","DOI":"10.1155\/2022\/5785025","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T16:50:10Z","timestamp":1664470210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[Retracted] Mechanism of Anti\u2010Inflammatory Drugs in the Early Treatment of Oral Gingival Mucosa and Soft Tissue Trauma"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yanfeng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-7959","authenticated-orcid":false,"given":"Weihui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani12040524"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182111491"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.52198\/21.sti.39.os1465"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2021.04.004"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2021.04.003"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-00950-y"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118811"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-021-01602-x"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/632\/5\/052012"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5246725"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2018.02.065"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000002774"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12167"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1145\/3072959.3073685"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1109\/tro.2015.2402531"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.12659\/msmbr.905056"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1835195"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2018-0079"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00262-0"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2016.11.012"}],"updated-by":[{"DOI":"10.1155\/2023\/9793546","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"record-id":"60702"},{"DOI":"10.1155\/2023\/9793546","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000}}],"container-title":["Contrast Media &amp; Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2022\/5785025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2022\/5785025.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/5785025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T02:38:58Z","timestamp":1721788738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/5785025"}},"subtitle":[],"editor":[{"given":"Sandip K","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/5785025"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5785025","archive":["Portico"],"relation":{},"ISSN":["1555-4309","1555-4317"],"issn-type":[{"value":"1555-4309","type":"print"},{"value":"1555-4317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5785025"}}