{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:24:01Z","timestamp":1762341841468,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Science and Technology Plan Project","award":["JCYJ20190812161001790","81973602"],"award-info":[{"award-number":["JCYJ20190812161001790","81973602"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ20190812161001790","81973602"],"award-info":[{"award-number":["JCYJ20190812161001790","81973602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,5,21]]},"abstract":"<jats:p>Background. Chronic kidney disease (CKD) is a major public health problem worldwide. Treatment with renin-angiotensin system inhibitors can achieve only partial efficacy on renal function decline and renal fibrosis in CKD patients. Huangqi-Danshen decoction (HDD) is a basic Chinese herbal pair which is commonly used to treat CKD with good efficacy.Objectives. The current study aimed to investigate the effect of perindopril erbumine (PE), an angiotensin-converting enzyme inhibitor, combined with HDD on adenine-induced CKD rat model and explore the possible mechanism from Sirtuin3\/mitochondrial dynamics pathway Method. CKD rat model was established by feeding of 0.75% w\/w adenine containing diet for 3 weeks. At the same time, the treatment groups were given PE (0.42\u2009mg\/kg\/d) or HDD (4.7\u2009g\/kg\/d) or PE combined with HDD by gavage for 4 weeks. Renal function was evaluated by the levels of serum creatinine (Scr) and blood urea nitrogen (BUN). The renal pathological injury was observed by periodic acid-Schiff (PAS) and Masson\u2019s trichrome staining. Proteins expression was determined by Western blot analysis. Mitochondrial morphology was observed by transmission electron microscopy. Results. PE in combination with HDD significantly improved renal function, reduced tubular injury and interstitial fibrosis in adenine-induced CKD rats. Moreover, PE\u2009+\u2009HDD treatment mainly activated the Sirtuin3 expression level. In addition, PE\u2009+\u2009HDD exhibited bidirectional regulation on mitochondrial dynamics by suppressing mitochondrial fission protein dynaminrelated protein 1 expression and elevating mitochondrial fusion protein optic atrophy 1 expression, resulted in restraint of mitochondrial fragmentation.Conclusion. The combination of PE and HDD attenuated adenine-induced CKD in rats, which was possibly associated with Sirtuin3\/mitochondrial dynamics pathway.<\/jats:p>","DOI":"10.1155\/2022\/5812105","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T20:05:13Z","timestamp":1653163513000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3\/Mitochondrial Dynamics Pathway"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0539-2675","authenticated-orcid":true,"given":"Xian","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Weng","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlan","family":"Lao","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruyu","family":"Deng","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Nanjing University of Chinese Medicine, Shenzhen 518000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-0431","authenticated-orcid":true,"given":"Jiandong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-0978","authenticated-orcid":true,"given":"Shudong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-7836","authenticated-orcid":true,"given":"Xinhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.05.032"},{"issue":"10225","key":"2","first-page":"709","article-title":"Global, regional, and national burden of chronic kidney disease","volume":"395","author":"B. 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