{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:31:37Z","timestamp":1792679497695,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2022,11,30]]},"abstract":"<jats:p>Objective. The objective of this study is to analyze the impact of declining kidney function on the occurrence of the slow-flow\/no-reflow phenomenon in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI (pPCI), as well as the analysis of the prognostic impact of the slow-flow\/no-reflow phenomenon on short- and long-term mortality in these patients. Methods. We analyzed 3,115 consecutive patients. A value of the glomerular filtration rate (eGFR) at the time of admission of eGFR &lt;90\u2009ml\/min\/m2 was considered a low baseline eGFR. The follow-up period was 8 years. Results. The slow-flow\/no-reflow phenomenon through the IRA was registered in 146 (4.7%) patients. Estimated GFR of &lt;90\u2009ml\/min\/m2 was an independent predictor for the occurrence of the slow-flow\/no-reflow phenomenon (OR 2.91, 95% CI 1.25\u20133.95, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001), and the risk for the occurrence of the slow-flow\/no-reflow phenomenon increased with the decline of the kidney function: eGFR 60\u201389\u2009ml\/min\/m2: OR 1.94 (95% CI 1.22\u20133.07, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009=\u20090.005), eGFR 45\u201359\u2009ml\/min\/m2: OR 2.55 (95% CI 1.55\u20134.94, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001), eGFR 30\u201344\u2009ml\/min\/m2: OR 2.77 (95% CI 1.43\u20135.25, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001), eGFR 15\u201329\u2009ml\/min\/m2: OR 5.84 (95% CI 2.84\u20138.01, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001). The slow-flow\/no-reflow phenomenon was a strong independent predictor of short- and long-term all-cause mortality: 30-day mortality (HR 2.62, 95% CI 1.78\u20133.57, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                     <\/k:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001) and 8-year mortality (HR 2.09, 95% CI 1.49\u20132.09, <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                     <\/m:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001). Conclusion. Reduced baseline kidney function was an independent predictor for the occurrence of the slow-flow\/no-reflow phenomenon, and its prognostic impact started with the mildest decrease in eGFR (below 90\u2009ml\/min\/m2) and increased with its further decline. The slow-flow\/no-reflow phenomenon was a strong independent predictor of mortality in the short- and long-term follow-up of the analyzed patients.<\/jats:p>","DOI":"10.1155\/2022\/5815274","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T17:51:07Z","timestamp":1669917067000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["The Impact of Kidney Function on the Slow-Flow\/No-Reflow Phenomenon in Patients Treated with Primary Percutaneous Coronary Intervention: Registry Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-1641","authenticated-orcid":true,"given":"Lidija","family":"Savic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Emergency Hospital & Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Mrdovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Emergency Hospital & Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milika","family":"Asanin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Emergency Hospital & Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Center for Medical Biochemistry, Emergency Hospital, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratko","family":"Lasica","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Emergency Hospital & Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Krljanac","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Emergency Hospital & Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dubravka","family":"Rajic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"},{"name":"Emergency Hospital & Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damjan","family":"Simic","sequence":"additional","affiliation":[{"name":"Emergency Hospital & Cardiology Clinic, University Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2016.04.006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-21-0221"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2018.01.032"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/0003319714546738"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/mca.0b013e3283108fef"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/mca.0000000000000108"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2020.12.008"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-013-0379-1"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.102867"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1177\/0003319712474336"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.5152\/anatoljcardiol.2021.846"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.03.057"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-20-1115"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2007050554"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300024"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1177\/2048872613514013"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.5152\/AnatolJCardiol.2021.35332"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"19","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1093\/eurheartj\/ehaa650","article-title":"Nomenclature for kidney function and disease-executive summary and glossary from a Kidney isease: mproving Global Outcomes (KDIGO) consensus conference","volume":"41","author":"A. 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