{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:41:32Z","timestamp":1740152492113,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Basic Research Program","award":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"],"award-info":[{"award-number":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"]}]},{"name":"National Clinical Research Center for Infectious Diseases","award":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"],"award-info":[{"award-number":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"],"award-info":[{"award-number":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"],"award-info":[{"award-number":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"],"award-info":[{"award-number":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Capital\u2019s Funds for Health Improvement and Research, China","award":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"],"award-info":[{"award-number":["2015CB554000","NCRC-ID202106","81373067","81520108021","91529305","81673250","81521091","2017ZX10201201-006","GWV-10.1-XK17","2020-1-5031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,10,27]]},"abstract":"<jats:p>Background. Activation of chronic hepatitis B virus (HBV) infection is an important cause of acute-on-chronic liver failure (ACLF). However, the effect of HBV-ACLF episode on hepatocellular carcinoma (HCC) occurrence remains largely unknown. Methods. A total of 769 HBV-ACLF patients and 2114 HBV-related chronic liver disease (HBV-CLD) patients diagnosed between August 1998 and December 2011 were enrolled in this prospective cohort study. Of the HBV-CLD patients, 380 received lifetime antiviral treatment with nucleos(t)ide analogues. Propensity score matching was applied to reduce baseline differences between HBV-ACLF and HBV-CLD cohorts. Results. The survival rate of HBV-ACLF patients was 53.6%, 50.3%, 47.8%, and 46.2% at 90-day, 1-year, 5-year, and 10-year, respectively. The cumulative incidence of HCC was lower in HBV-ACLF cohort with 369 eligible patients survived for &gt;90 days than in HBV-CLD cohort with the 380 patients (5.77\/1,000 vs. 9.78\/1,000 person-years, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.0497<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). HBV-ACLF episode decreased HCC risk regardless of liver cirrhosis, and in patients without family history of HCC. Multivariate Cox analyses indicated that male, increasing age, liver cirrhosis, and platelet count (\u2264100\u2009\u00d7\u2009109\/L) increased, whereas HBV-ACLF episode decreased, HCC risk independently. In the propensity score-matched cohorts, HBV-ACLF episode reduced HCC incidence (10.20\/1,000 vs. 4.66\/1,000 person-years, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.0326<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The area under curve of nomogram was 0.812 for 3-year HCC probability. Conclusions. HBV-ACLF episode decreases HCC occurrence in chronic HBV patients. Older age and liver cirrhosis independently increased HCC occurrence. A nomogram-enrolled episode of ACLF reliably predicts the occurrence of HCC.<\/jats:p>","DOI":"10.1155\/2022\/5873002","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T23:20:30Z","timestamp":1666912830000},"page":"1-13","source":"Crossref","is-referenced-by-count":2,"title":["A Lower HCC Incidence in Chronic HBV-Infected Patients Recovered from Acute-on-Chronic Liver Failure: A Prospective Cohort Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1047-7059","authenticated-orcid":true,"given":"Jianhua","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-0885","authenticated-orcid":true,"given":"Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Senior Department of Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China"},{"name":"Laboratory of Translational Medicine, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-739X","authenticated-orcid":true,"given":"Rui","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-5974","authenticated-orcid":true,"given":"Haibin","family":"Su","sequence":"additional","affiliation":[{"name":"Senior Department of Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 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