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The present in silico investigation was performed to reveal the biophysical characteristics and immunogenic epitopes of the 14 blood\u2010stage proteins of the <jats:italic>P. falciparum<\/jats:italic> using comprehensive immunoinformatics approaches. For this aim, various web servers were employed to predict subcellular localization, antigenicity, allergenicity, solubility, physicochemical properties, posttranslational modification sites (PTMs), the presence of signal peptide, and transmembrane domains. Moreover, structural analysis for secondary and 3D model predictions were performed for all and stable proteins, respectively. Finally, human helper T lymphocyte (HTL) epitopes were predicted using HLA reference set of IEDB server and screened in terms of antigenicity, allergenicity, and IFN\u2010<jats:italic>\u03b3<\/jats:italic> induction as well as population coverage. Also, a multiserver B\u2010cell epitope prediction was done with subsequent screening for antigenicity, allergenicity, and solubility. 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