{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:49:26Z","timestamp":1747190966489,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,6,20]]},"abstract":"<jats:p>In order to investigate the therapeutic effect of norepinephrine on patients with sepsis and the effect of echocardiography on the diagnosis of cardiac function in patients with sepsis, 86 patients with sepsis were selected as research objects and randomly divided into two groups. Patients in the control group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>N<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>43<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> cases) received conventional treatment (1~15\u2009\u03bcg\/<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>kg<\/c:mtext>\n                        <c:mo>\u2217<\/c:mo>\n                        <c:mi mathvariant=\"normal\">min<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula> dopamine), and those in the experimental group (<jats:inline-formula>\n                     <f:math xmlns:f=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <f:mi>N<\/f:mi>\n                        <f:mo>=<\/f:mo>\n                        <f:mn>43<\/f:mn>\n                     <\/f:math>\n                  <\/jats:inline-formula> cases) received conventional treatment+norepinephrine therapy (0.05~0.5\u2009<jats:inline-formula>\n                     <h:math xmlns:h=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <h:mi>\u03bc<\/h:mi>\n                        <h:mtext>g<\/h:mtext>\n                        <h:mo>\u2217<\/h:mo>\n                        <h:mtext>kg<\/h:mtext>\n                     <\/h:math>\n                  <\/jats:inline-formula>-1\/min). The clinical efficacy, cardiac ultrasonography results, and hemodynamic indexes of patients between the two groups were analyzed and compared. The results showed that the total effective rate of treatment in the experimental group (97.7%) was significantly higher than that in the control group (81.4%) (<jats:inline-formula>\n                     <j:math xmlns:j=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <j:mi>P<\/j:mi>\n                        <j:mo>&lt;<\/j:mo>\n                        <j:mn>0.05<\/j:mn>\n                     <\/j:math>\n                  <\/jats:inline-formula>). The maximum, minimum, and average values of mitral valve E peak flow velocity (VEpeak) and left ventricular outflow tract peak flow velocity (Vpeak), respiratory variability of mitral valve E peak flow velocity (\u0394VEpeak), and respiratory variability of peak flow velocity (\u0394Vpeak) were all significantly greater than those of the control group (<jats:inline-formula>\n                     <l:math xmlns:l=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <l:mi>P<\/l:mi>\n                        <l:mo>&lt;<\/l:mo>\n                        <l:mn>0.05<\/l:mn>\n                     <\/l:math>\n                  <\/jats:inline-formula>). The area under the receiver operating characteristic curve (AUC) of \u0394VEpeak and \u0394Vpeak for predicting positive volume response in patients with sepsis was 0.934 and 0.913, respectively; the sensitivity was 0.828 and 0.827; the specificity was 0.936 and 0.893; and the Youden indices were 0.765 and 0.712, respectively. In short, norepinephrine had a high total response rate in patients with sepsis, and echocardiography can well evaluate the effect of norepinephrine on cardiac function in patients with sepsis, which is worthy of further promotion.<\/jats:p>","DOI":"10.1155\/2022\/5896791","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T23:22:10Z","timestamp":1655767330000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Effect Evaluation of Norepinephrine on Cardiac Function in Patients with Sepsis by Cardiac Ultrasound Imaging"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-7590","authenticated-orcid":true,"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Xuzhou Medical University Affiliated Hospital of Lianyungang, Lianyungang, 222000 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-7413","authenticated-orcid":true,"given":"Yuyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Xuzhou Medical University Affiliated Hospital of Lianyungang, Lianyungang, 222000 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6961-0005","authenticated-orcid":true,"given":"Baocheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Xuzhou Medical University Affiliated Hospital of Lianyungang, Lianyungang, 222000 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4178-3326","authenticated-orcid":true,"given":"Xianjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Xuzhou Medical University Affiliated Hospital of Lianyungang, Lianyungang, 222000 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Current status of septic cardiomyopathy: basic science and clinical progress","volume":"11","author":"H. 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