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Propolis was traditionally used as a wound healing substance, cosmetic, medicine, and many other conditions. Till now, there is no definite curable treatment for most cancers and chemotherapeutic drugs and drugs used for targeted therapies have serious side effects. According to a recent research, natural products are becoming increasingly essential in cancer prevention. Natural products are a great source of potential therapeutic agents, especially in the treatment of cancer. Previous studies have reported that the presence of caffeic acid phenethyl ester (CAPE), artepillin C, and chrysin is responsible for the anticancer potential of propolis. Most of the previous studies suggested that propolis and its active compounds inhibit cancer progression by targeting multiple signaling pathways including phosphoinositide 3-kinases (PI3K)\/Akt and mitogen-activated protein kinase (MAPK) signaling molecules, and induce cell cycle arrest. Induction of apoptosis by propolis is mediated through extrinsic and intrinsic apoptotic pathways. The aim of this review is to highlight and summarize the molecular targets and anticancer potential of propolis and its active compounds on cell survival, proliferation, metastasis, and apoptosis in cancer cells.<\/jats:p>","DOI":"10.1155\/2022\/5901191","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T21:05:06Z","timestamp":1655499906000},"page":"1-14","source":"Crossref","is-referenced-by-count":68,"title":["An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-5527","authenticated-orcid":true,"given":"Perumal","family":"Elumalai","sequence":"first","affiliation":[{"name":"Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natarajan","family":"Muninathan","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, MAHER University, Enathur, Chennai, Tamil Nadu 631552, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhasivan T.","family":"Megalatha","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, MAHER University, Enathur, Chennai, Tamil Nadu 631552, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arumugam","family":"Suresh","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, MAHER University, Enathur, Chennai, Tamil Nadu 631552, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalimuthu Senthil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Swamy Vivekanandha Medical College Hospital and Research Institute, Elayampalayam, Tiruchengode, Namakkal, Tamil Nadu 637205, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Jhansi","sequence":"additional","affiliation":[{"name":"Zebrafish Developmental Biology Laboratory, AUKBC Research Centre, Anna University, Chromepet, Chennai 600044, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuppuswamy","family":"Kalaivani","sequence":"additional","affiliation":[{"name":"Research Center for Cellular Genomics and Cancer Research, Sree Balaji Medical College and Hospital, Chromepet, Chennai 44, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-2930","authenticated-orcid":true,"given":"Gunasekaran","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, College of Health Sciences, Dambi Dollo University, Dembi Dollo, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1177\/1534735409357934"},{"issue":"6","key":"3","first-page":"1015","article-title":"Molecular mechanism of apoptosis induced by PsL5F in human anaplastic thyroid carcinoma FRO cells","volume":"40","author":"Z. 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