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It is reported that medicine food homology (MFH) plants have multiple nutraceutical compounds. Based on our literature research, 20 MFH plants caught our attention because they contain three popular antiosteoporosis compounds simultaneously: quercetin, rutin, and kaempferol. According to traditional Chinese medicine (TCM), their characteristics including natures, flavors, attributive to meridian tropism, and efficacies were listed. The relationships between TCM efficacies, such as \u201cheat clearing,\u201d \u201ctonic,\u201d and \u201cthe interior warming,\u201d and antiosteoporosis pharmacological actions such as antioxidant and immune regulation were discussed. The in vivo antiosteoporosis effects of the 20 MFH plants were summarized. The in vitro antiosteoporosis activities and related mechanisms of the 20 plants and quercetin, rutin, kaempferol were detailed. The TGF-\u03b2-Smad signaling, fibroblast growth factor, and Wnt\/\u03b2-catenin signaling on bone formation and the RANKL signaling, NF-\u03baB signaling, and macrophage-colony-stimulating factor on bone resorption were identified. From food point, these 20 MFH plants could be classified as condiment, vegetable, fruit, tea and related products, beverage, etc. Based on the above discussion, these 20 MFH plants could be used as daily food supplements for the prevention and treatment against osteoporosis.<\/jats:p>","DOI":"10.1155\/2022\/5902293","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T23:20:08Z","timestamp":1648768808000},"page":"1-20","source":"Crossref","is-referenced-by-count":23,"title":["Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics, In Vivo and In Vitro Activities, Potential Mechanisms, and Food Functions"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-1809","authenticated-orcid":true,"given":"Dayue","family":"Shen","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-3590","authenticated-orcid":true,"given":"Yating","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-5729","authenticated-orcid":true,"given":"Xilan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8882-0278","authenticated-orcid":true,"given":"Le","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-6510","authenticated-orcid":true,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-811X","authenticated-orcid":true,"given":"Yuanping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People\u2019s Hospital), Taiyuan 030012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-062X","authenticated-orcid":true,"given":"Hui","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People\u2019s Hospital), Taiyuan 030012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116820"},{"issue":"4","key":"2","first-page":"317","article-title":"Epidemiological survey of osteoporosis in China and the results of the \u201chealthy bones\u201d special action released","volume":"12","author":"Osteoporosis and Bone Mineral Disease Branch of Chinese Medical Association","year":"2019","journal-title":"Chinese Journal of Osteoporosis and Bone Mineral Research"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S103845"},{"key":"4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110191","article-title":"Targeting filamin a alleviates ovariectomy-induced bone loss in mice via the WNT\/\u03b2-catenin signaling pathway","volume":"90","author":"C. 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