{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:23:00Z","timestamp":1790810580464,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009399","name":"Peking University Third Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,7,31]]},"abstract":"<jats:p>The voltage-dependent anion channel 1 (VDAC1), a pore protein located in the outer mitochondrial membrane, has been confirmed to be related to cancer in cell or animal evidence. However, there is no available pan-cancer analysis of VDAC1. Herein, we investigated the potential roles of VDAC1 in tumorigenesis and progression based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Clinical Proteomic Tumor Analysis Consortium (CPTAC) datasets. The expression of VDAC1 increased in most cancers, and the upregulation of VDAC1 distinctly correlated with the poor prognosis in patients, including breast invasive carcinoma, cervical squamous cell carcinoma, pancreatic adenocarcinoma, lung adenocarcinoma, and skin cutaneous melanoma. We also found VDAC1 S104 phosphorylation raised in various cancers, such as breast cancer, colon cancer, and lung adenocarcinoma. Moreover, the expression of VDAC1 was related to the estimated infiltration value of cancer-associated fibroblasts in bladder urothelial carcinoma, colon adenocarcinoma, kidney renal papillary cell carcinoma, and testicular germ cell tumors. At last, we showed that VDAC1-related oxidative phosphorylation and metabolic regulation may partially explain its association with tumorigenesis and progression. Taken together, this pan-cancer analysis provides relatively comprehensive information on the potential value of VDAC1 as a prognostic biomarker and therapeutic target.<\/jats:p>","DOI":"10.1155\/2022\/5946110","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:32:17Z","timestamp":1659328337000},"page":"1-19","source":"Crossref","is-referenced-by-count":12,"title":["Pan-Cancer Analysis of Voltage-Dependent Anion Channel (VDAC1) as a Cancer Therapeutic Target or Diagnostic Biomarker"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-1047","authenticated-orcid":true,"given":"Zhitong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Peking University Third Hospital; Institute for Drug Evaluation, Peking University Health Science Center; Therapeutic Drug Monitoring and Clinical Toxicology Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-0384","authenticated-orcid":true,"given":"Yinchu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Peking University Third Hospital; Institute for Drug Evaluation, Peking University Health Science Center; Therapeutic Drug Monitoring and Clinical Toxicology Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7064-4459","authenticated-orcid":true,"given":"Zaiwei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Peking University Third Hospital; Institute for Drug Evaluation, Peking University Health Science Center; Therapeutic Drug Monitoring and Clinical Toxicology Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-3496","authenticated-orcid":true,"given":"Rongsheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Peking University Third Hospital; Institute for Drug Evaluation, Peking University Health Science Center; Therapeutic Drug Monitoring and Clinical Toxicology Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.059"},{"key":"3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4939-3578-9_5","article-title":"The gene expression omnibus database","volume":"1418","author":"E. Clough","year":"2016","journal-title":"Methods in Molecular Biology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2010.03.002"},{"issue":"13, article 3348","key":"5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133348","article-title":"VDAC1 and the TSPO: expression, interactions, and associated functions in health and disease states","volume":"20","author":"V. Shoshan-Barmatz","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"6","article-title":"VDAC modulation of cancer metabolism: advances and therapeutic challenges","volume":"12, article 742839","author":"K. A. Heslop","year":"2021","journal-title":"Frontiers in Physiology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.9.12.11879"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9943"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.04.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803614200"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00108"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1101\/gr.229102"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst012"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13528-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz430"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2020.06.044"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004088"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-5-p3"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa407"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw937"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-293"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0386"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-14-1397"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404720101"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1021\/pr800364d"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-019-09959-0"},{"issue":"11, article 1485","key":"27","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111485","article-title":"VDAC1 at the intersection of cell metabolism, apoptosis, and diseases","volume":"10","author":"V. Shoshan-Barmatz","year":"2020","journal-title":"Biomolecules"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-008-9139-9"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110094"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110927200"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-008-9165-7"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2018.02.002"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210220"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7647139"},{"issue":"12, article 499","key":"35","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10120499","article-title":"Mitochondrial VDAC1 silencing leads to metabolic rewiring and the reprogramming of tumour cells into advanced differentiated states","volume":"10","author":"T. Arif","year":"2018","journal-title":"Cancers"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1021\/pr4002096"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6704"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1711317"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02205-y"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.7150\/thno.41001"},{"issue":"11, article 3484","key":"41","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113484","article-title":"Evidences of a direct relationship between cellular fuel supply and ciliogenesis regulated by hypoxic VDAC1-\u0394C","volume":"12","author":"M. Meyenberg Cunha-de Padua","year":"2020","journal-title":"Cancers"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.03.068"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03342-8"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/5946110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/5946110.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/5946110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:32:28Z","timestamp":1659328348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/5946110\/"}},"subtitle":[],"editor":[{"given":"Atif Ali","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,31]]},"references-count":43,"alternative-id":["5946110","5946110"],"URL":"https:\/\/doi.org\/10.1155\/2022\/5946110","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,31]]}}}