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Vitamin D is a fat-soluble sterol derivative that not only participates in calcium and phosphorus metabolism but also acts as an immunomodulatory role by binding to nuclear vitamin D receptors to regulate the expression of transcription factors. Increasing evidence has shown that vitamin D has immunoregulation and anti-inflammatory effects, and it may play a role in T cell regulatory responses due to downregulation in the expression of cathepsin G and inhibition of CD4+ T cell activation and protection of \u03b2 cells from immune attack and is beneficial in decreasing oxidative stress in T1DM patients. Epidemiologic evidence demonstrates involvement of vitamin D deficiency in T1DM pathogenesis, with the immune system improperly targeting and destroying its own islet \u03b2 cells. In addition, polymorphisms in genes critical for vitamin D metabolism may increase the risk of islet autoimmunity and T1DM. In this paper, the relationship between vitamin D deficiency and the molecular mechanism of T1DM was discussed.<\/jats:p>","DOI":"10.1155\/2022\/5953562","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T21:20:07Z","timestamp":1662153607000},"page":"1-8","source":"Crossref","is-referenced-by-count":45,"title":["Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-5599","authenticated-orcid":true,"given":"Lian-Ping","family":"He","sequence":"first","affiliation":[{"name":"School of Medicine, Taizhou University, Jiaojiang, 318000 Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Song","sequence":"additional","affiliation":[{"name":"School of Medicine, Taizhou University, Jiaojiang, 318000 Zhejiang, 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