{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:56:54Z","timestamp":1791622614458,"version":"4.3.4"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Traditional Chinese Medicine Science and Technology in Jiangsu Province","award":["2020ZX15"],"award-info":[{"award-number":["2020ZX15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,3,29]]},"abstract":"<jats:p>Background. Cerebral infarction (CI) is a common brain disease in clinical practice, which is mainly due to the pathological environment of ischemia and hypoxia caused by difficult cerebral circulation perfusion function, resulting in ischemic necrosis of local brain tissue and neurological impairment. In traditional Chinese medicine (TCM) theory, CI is mainly due to blood stasis in the brain. Therefore, blood-activating and stasis-dissipating drugs are often used to treat CI in clinical practice. Salvia miltiorrhiza Bunge (SMB) is a kind of traditional Chinese medicine with good efficacy in promoting blood circulation and removing blood stasis, and treatment of CI with it is a feasible strategy. Based on the above analysis, we chose network pharmacology to investigate the feasibility of SMB in the treatment of CI and to study the possible molecular mechanisms by providing some reference for the treatment of CI with TCM. Methods. The active ingredients and related targets of SMB were obtained through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, and CI-related targets were obtained from the GeneCards and DisGeNET databases. The target of SMB for the treatment of CI was obtained using Cytoscape software and visualized. GO and KEGG enrichment analysis was performed based on \u201cclusterProfiler\u201d within R, and the prediction results were validated by molecular docking technique. Results. By constructing a compound-target (C-T) network, it was found that the active components in SMB mainly treated CI by regulating key proteins such as AKT1, IL-6, and EGFR. These key proteins mainly involve in pathways such as immune regulation, cancer and lipid metabolism, such as lipid and atherosclerosis, chemical carcinogenesis-receptor activation pathways, and IL-17 signaling pathway. In the GO term, it mainly regulates the response to steroid hormones, membrane rafts, and G protein-amine receptor coupled activity. Eventually, we verified that the luteolin and tanshinone IIA components in SMB have a good possibility of action with AKT1 and IL-6 by in silico techniques, indicating that SMB has some scientificity in the treatment of CI. Conclusion. SMB mainly treats CI by regulating 94 proteins involved in lipid and atherosclerosis, chemical carcinogenesis-receptor activation, and IL-17 signaling pathway. Our research strategy provided a template for the drug development of TCM for the treatment of CI.<\/jats:p>","DOI":"10.1155\/2022\/5992394","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T23:50:10Z","timestamp":1648597810000},"page":"1-12","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Mechanism of Salvia miltiorrhiza Bunge in Treating Cerebral Infarction"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xietao","family":"Ye","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China"},{"name":"Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Tiantai County Food and Drug Testing Center, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-4032","authenticated-orcid":true,"given":"Songhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-4434","authenticated-orcid":true,"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangxi University of Chinese Medicine, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-1630","authenticated-orcid":true,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China"},{"name":"Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519879292"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.621169"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-03026-y"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9945633"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00568"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16023579"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.618844"},{"issue":"7","key":"8","first-page":"1521","article-title":"[Treatment of COVID-19 guided by holistic view of traditional Chinese medicine\u2014therapy aimed at both viral and host]","volume":"45","author":"R. 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