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Recently, a stem cell application is emerging as promising adjuvant therapy. We presented available remedies by conducting a literature review on the application, safety, and efficacy of stem cell therapy. Relevant literature, including randomized control trials and article journals, was obtained from reputable search engines (PubMed, Scopus, and Web of Science). We analyzed five credible cohorts, with variable sources of stem cells, in a total of 216 participants, 151 males and 65 females, age (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>mean<\/a:mtext>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mtext>SD<\/a:mtext>\n                     <\/a:math>\n                  <\/jats:inline-formula>) of <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mn>64.5<\/c:mn>\n                        <c:mo>\u00b1<\/c:mo>\n                        <c:mn>9.6<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula> years. With an average success of 86.41% in all Wagner-II lesions, mesenchymal SCA (stem cell application) is safe and effective, hence can significantly prevent limb amputation.<\/jats:p>","DOI":"10.1155\/2022\/6028743","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T14:35:09Z","timestamp":1670337309000},"page":"1-12","source":"Crossref","is-referenced-by-count":25,"title":["Stem Cell Therapy for Diabetic Foot Ulcers: Theory and Practice"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-1500","authenticated-orcid":true,"given":"David Lubasi","family":"Nalisa","sequence":"first","affiliation":[{"name":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China"},{"name":"Medical Key Laboratory of Hereditary Rare Diseases of Henan, Luoyang, 471003, China"},{"name":"Luoyang Sub-Center of National Clinical Research Center for Metabolic Diseases, Luoyang, 471003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-2116","authenticated-orcid":true,"given":"Md.","family":"Moneruzzaman","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine and Physiotherapy, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-6202","authenticated-orcid":true,"given":"Geoffrey J.","family":"Changwe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, National Heart Hospital, Off-Airport Road, 10101 Lusaka, Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-1739","authenticated-orcid":true,"given":"Youchaou","family":"Mobet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7396-1310","authenticated-orcid":true,"given":"Li Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China"},{"name":"Medical Key Laboratory of Hereditary Rare Diseases of Henan, Luoyang, 471003, China"},{"name":"Luoyang Sub-Center of National Clinical Research Center for Metabolic Diseases, Luoyang, 471003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-3398","authenticated-orcid":true,"given":"Yu Jin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China"},{"name":"Medical Key Laboratory of Hereditary Rare Diseases of Henan, Luoyang, 471003, China"},{"name":"Luoyang Sub-Center of National Clinical Research Center for Metabolic Diseases, Luoyang, 471003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-7989","authenticated-orcid":true,"given":"Hong Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China"},{"name":"Medical Key Laboratory of Hereditary Rare Diseases of Henan, Luoyang, 471003, China"},{"name":"Luoyang Sub-Center of National Clinical Research Center for Metabolic Diseases, Luoyang, 471003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i1.37"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2019.24.Sup3.S14"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.08.244"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0424"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"issue":"3","key":"6","first-page":"275","article-title":"Treatment of diabetic foot ulcers","volume":"50","author":"S. 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