{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:45:38Z","timestamp":1787928338986,"version":"build-2784847793"},"reference-count":141,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T00:00:00Z","timestamp":1661644800000},"content-version":"vor","delay-in-days":239,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["R.G.P. 2\/131\/43"],"award-info":[{"award-number":["R.G.P. 2\/131\/43"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over the period of time. AD is characterized by cognitive dysfunctions, behavioural disability, and psychological impairments due to the accumulation of amyloid beta (A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) peptides and neurofibrillary tangles (NFT). Several research reports have shown that flavonoids are the polyphenolic compounds that significantly improve cognitive functions and inhibit or delay the amyloid beta aggregation or NFT formation in AD. Current research has uncovered that dietary use of flavonoid\u2010rich food sources essentially increases intellectual abilities and postpones or hinders the senescence cycle and related neurodegenerative problems including AD. During AD pathogenesis, multiple signalling pathways are involved and to target a single pathway may relieve the symptoms but not provides the permanent cure. Flavonoids communicate with different signalling pathways and adjust their activities, accordingly prompting valuable neuroprotective impacts. Flavonoids likewise hamper the movement of obsessive indications of neurodegenerative disorders by hindering neuronal apoptosis incited by neurotoxic substances. In this short review, we briefly discussed about the classification of flavonoids and their neuroprotective properties that could be used as a potential source for the treatment of AD. In this review, we also highlight the structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6038996","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T14:50:06Z","timestamp":1661698206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-0102","authenticated-orcid":false,"given":"Tarun","family":"Minocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-597X","authenticated-orcid":false,"given":"Hareram","family":"Birla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad A.","family":"Obaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-0195","authenticated-orcid":false,"given":"Vipin","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-234X","authenticated-orcid":false,"given":"P.","family":"Sushma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-139X","authenticated-orcid":false,"given":"Chandan","family":"Shivamallu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3893-4282","authenticated-orcid":false,"given":"Mohammed","family":"Al-Shehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al-Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-8981","authenticated-orcid":false,"given":"Maria A.","family":"Tikhonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-7284","authenticated-orcid":false,"given":"Sanjeev Kumar","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-1129","authenticated-orcid":false,"given":"Burkhard","family":"Poeggeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-3227","authenticated-orcid":false,"given":"Divakar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-6240","authenticated-orcid":false,"given":"Sandeep Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,28]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2016.06.009"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-18165-z"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666191008103141"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7567"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-009-0135-4"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2017.00019"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202100976"},{"key":"e_1_2_13_8_2","first-page":"1","volume-title":"Nutritional Neuroscience","author":"Ramezani M.","year":"2022"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26134021"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-018-0226-1"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15117792"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.5772\/67861"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030554"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2015.09.012"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7043213"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061267"},{"key":"e_1_2_13_17_2","volume-title":"The flavonoids: advances in research since 1980","author":"Harborne J. B.","year":"2013"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867013373011"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2012.00222"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(02)00208-5"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00155"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00298-X"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2016.1238026"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2022.03.011"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2016.41"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.012948"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.10.3248S"},{"key":"e_1_2_13_28_2","volume-title":"Anthocyanins: dietary sources, bioavailability, human metabolic pathways, and potential anti-neuroinflammatory activity","author":"Hornedo-Ortega R.","year":"2022"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.4172\/pharmaceutical-sciences.1000397"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02076-7"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00164.x"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1438"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(76)90059-9"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601917"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.536839"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22516"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.17.1.17"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901659116"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aoas.2021.04.001"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR1021-531R"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1703"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104907"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2017.06.003"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041010"},{"key":"e_1_2_13_46_2","first-page":"97","article-title":"Anti-carcinogenic possessions of citrus peel extract and flavonoids","volume":"4","author":"Shafique B.","year":"2019","journal-title":"Advanced Food and Nutritional Sciences"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.30621\/jbachs.2019.555"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.10033"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6208"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666181001104550"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.07.016"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/840542"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557519666190617150051"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020099"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200122122512"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf204452y"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/life12040591"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.565700"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-020-00696-0"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020346"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt125"},{"key":"e_1_2_13_62_2","first-page":"108","article-title":"Medicinal plant for curing Alzheimer\u2019s disease","volume":"1","author":"Singh A. K.","year":"2010","journal-title":"International Journal of Pharmaceutical & Biological Archive"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.80102"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-200228"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.140293"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0364-08.2008"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00344.x"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9000-x"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.10.032"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.294025"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32830b8ae1"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04841.x"},{"key":"e_1_2_13_73_2","article-title":"Modulation of pro-survival Akt\/PKB and ERK1\/2 signalling cascades by quercetin and its in vivo metabolites","volume":"35","author":"Spencer J.","year":"2003","journal-title":"Free Radical Biology and Medicine"},{"key":"e_1_2_13_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201400002"},{"key":"e_1_2_13_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9090927"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.01.030"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.055"},{"key":"e_1_2_13_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2070-z"},{"key":"e_1_2_13_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.07.023"},{"key":"e_1_2_13_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020493"},{"key":"e_1_2_13_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.010"},{"key":"e_1_2_13_82_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109106923"},{"key":"e_1_2_13_83_2","doi-asserted-by":"publisher","DOI":"10.1159\/000090736"},{"key":"e_1_2_13_84_2","doi-asserted-by":"publisher","DOI":"10.1017\/S000711459900080X"},{"key":"e_1_2_13_85_2","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451700109X"},{"key":"e_1_2_13_86_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.088518"},{"key":"e_1_2_13_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00895-8"},{"key":"e_1_2_13_88_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6571484"},{"key":"e_1_2_13_89_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00481"},{"key":"e_1_2_13_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.05.052"},{"key":"e_1_2_13_91_2","doi-asserted-by":"publisher","DOI":"10.5604\/12321966.1185777"},{"key":"e_1_2_13_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"},{"key":"e_1_2_13_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600549103"},{"key":"e_1_2_13_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.06.023"},{"key":"e_1_2_13_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(91)90609-V"},{"key":"e_1_2_13_96_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.1.115"},{"key":"e_1_2_13_97_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986711798184325"},{"key":"e_1_2_13_98_2","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2007-11-1210"},{"key":"e_1_2_13_99_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511093331902"},{"key":"e_1_2_13_100_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3501-06.2007"},{"key":"e_1_2_13_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07767"},{"key":"e_1_2_13_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(03)00089-3"},{"key":"e_1_2_13_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1991.tb00671.x"},{"key":"e_1_2_13_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02031-2"},{"key":"e_1_2_13_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.09.008"},{"key":"e_1_2_13_106_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509992364"},{"key":"e_1_2_13_107_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225339"},{"key":"e_1_2_13_108_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-1083-y"},{"key":"e_1_2_13_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.08.006"},{"key":"e_1_2_13_110_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00025"},{"key":"e_1_2_13_111_2","doi-asserted-by":"publisher","DOI":"10.1179\/147683009X423292"},{"key":"e_1_2_13_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.03.008"},{"key":"e_1_2_13_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110303"},{"key":"e_1_2_13_114_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9192"},{"key":"e_1_2_13_115_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123877"},{"key":"e_1_2_13_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp123"},{"key":"e_1_2_13_117_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129697.01779.0A"},{"key":"e_1_2_13_118_2","doi-asserted-by":"publisher","DOI":"10.2190\/Q6J4-R143-P630-KW41"},{"key":"e_1_2_13_119_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01605.x"},{"key":"e_1_2_13_120_2","volume-title":"Dementia: supporting people with dementia and their carers in health and social care","author":"National Collaborating Centre for Mental Health","year":"2011"},{"key":"e_1_2_13_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.037"},{"key":"e_1_2_13_122_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.4.418"},{"key":"e_1_2_13_123_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666201102102810"},{"key":"e_1_2_13_124_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-014-9466-z"},{"key":"e_1_2_13_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-019-00147-2"},{"key":"e_1_2_13_126_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871527319666200812224457"},{"key":"e_1_2_13_127_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-018-08521-7"},{"key":"e_1_2_13_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01182-4"},{"key":"e_1_2_13_129_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162750"},{"key":"e_1_2_13_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.04.033"},{"key":"e_1_2_13_131_2","doi-asserted-by":"publisher","DOI":"10.32604\/biocell.2022.015958"},{"key":"e_1_2_13_132_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665116000677"},{"key":"e_1_2_13_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.07.026"},{"key":"e_1_2_13_134_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/19.3.423"},{"key":"e_1_2_13_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-85852-6.00019-6"},{"key":"e_1_2_13_136_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010161"},{"key":"e_1_2_13_137_2","doi-asserted-by":"publisher","DOI":"10.1038\/513481a"},{"key":"e_1_2_13_138_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb500086e"},{"key":"e_1_2_13_139_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/66.6.1192"},{"key":"e_1_2_13_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(78)90020-1"},{"key":"e_1_2_13_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(86)90461-2"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/6038996.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/6038996.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/6038996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T21:20:12Z","timestamp":1748899212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/6038996"}},"subtitle":[],"editor":[{"given":"Amjad Islam","family":"Aqib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":141,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/6038996"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6038996","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6038996"}}