{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:00:18Z","timestamp":1788206418367,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,9,29]]},"abstract":"<jats:p>Objective: The study aimed to investigate the value of pulmonary function test (PFT) in evaluating and predicting pulmonary arterial hypertension (PAH) in patients with connective tissue disease (CTD). Methods: This was a prospective observational study recruiting patients diagnosed with CTD-PAH. Patients with interstitial lung disease and pulmonary hypertension induced by other causes were not eligible for enrollment. All patients were assessed for PAH every 1\u20133 months. A patient was considered to have clinical improvement if the grade of risk stratification declined or at least two parameters improved during follow-up, otherwise no improvement. Results: A total of 31 patients with CTD-PAH were recruited in this study. Nearly 70% of patients had declined forced vital capacity (FVC), 60% had declined total lung capacity and maximum expiratory flow at 50% of vital capacity, and 95% had normal or mild decline in forced expiratory volume in 1 second (FEV1)\/FVC. A decline in diffusing capacity of the lung for carbon monoxide (DLCO) was present in 96% of patients, and 60% were moderate to severe. Furthermore, 50% of patients had an FVC\/DLCO ratio of less than 1.4. Univariate analysis showed that FEV1\/FVC, DLCO, and FVC\/DLCO were associated with disease prognosis. After adjusting for age as a confounding factor, multivariate logistic regression analysis revealed that DLCO was an independent predictive factor for the prognosis of CTD-PAH. Conclusion: The pulmonary function of patients with CTD-PAH is abnormal in parameters such as lung volume, small airway, and gas exchange. PFT can reveal complex pathophysiological changes in the lungs of CTD-PAH patients and predict prognosis.<\/jats:p>","DOI":"10.1155\/2022\/6066291","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:20:26Z","timestamp":1664490026000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Pulmonary Function Test for Pulmonary Arterial Hypertension in Patients with Connective Tissue Disease"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-0812","authenticated-orcid":true,"given":"Jiangbiao","family":"Xiong","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-8558","authenticated-orcid":true,"given":"Jianbin","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-8533","authenticated-orcid":true,"given":"Yiping","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-1589","authenticated-orcid":true,"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-4912","authenticated-orcid":true,"given":"Rui","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0335OC"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1456OC"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02493-2016"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.898122"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0300"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2018.03.011"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/art.21433"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1269"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2135942"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197112"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102602"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S1579-2129(06)60245-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.12.015"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007249"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2962"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.03.009"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02964-9"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh067"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.032"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-1049ED"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1233307"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010132"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04937-w"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.05.609"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.6.473"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2012.55.8.297"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0899"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-020-00346-1"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00140109"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.933762"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-129"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1159\/000075204"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/art.22696"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh316"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.4103\/1687-8426.165937"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/6066291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/6066291.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/6066291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:20:28Z","timestamp":1664490028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/6066291\/"}},"subtitle":[],"editor":[{"given":"Qi-Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":40,"alternative-id":["6066291","6066291"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6066291","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}