{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:59:19Z","timestamp":1740153559526,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["IR03AI11771401A1"],"award-info":[{"award-number":["IR03AI11771401A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:p>Fetuin-A is an acute phase glycoprotein shown to counter in a regulatory manner proinflammatory cytokine production to maintain homeostasis during inflammation. We report here that in wild-type mice 12 days after Chlamydia muridarum (Cm) intranasal challenge, fetuin-A content in the lungs decreased 46%, while INF-\u03b3 increased 44%, consistent with a negative regulatory role of fetuin-A in inflammation. Importantly, the observed increased IFN-\u03b3 production was abrogated in fetuin-A-deficient AHSG mice suggesting that IFN-\u03b3 induction following Cm infection is fetuin-A dependent. Assessment of expression of genes associated with inflammation revealed fetuin-A-dependent upregulation of TBX21 (a Th1 cell-specific transcription factor) in the lungs of Cm-infected WT mice that correlated with IFN-\u03b3 induction. Additionally, the effect of fetuin-A deficiency in mounting an adaptive immune response to Cm infection was demonstrated using a splenocyte recall assay. Although preliminary in nature, these findings are suggestive of fetuin-A involvement following Cm pulmonary infection and underscores the need to investigate further the role of fetuin-A in the immune response and the consequences of its gene deletion.<\/jats:p>","DOI":"10.1155\/2022\/6082140","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T21:08:51Z","timestamp":1650402531000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Fetuin-A on Chlamydia muridarum Pulmonary Infection"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-5882","authenticated-orcid":true,"given":"Faria","family":"Mahjabeen","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-3366","authenticated-orcid":true,"given":"Jieh-Juen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-8127","authenticated-orcid":true,"given":"James P.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-5001","authenticated-orcid":true,"given":"Rishein","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-5306","authenticated-orcid":true,"given":"Bernard P.","family":"Arulanandam","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12281"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122033"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016945"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-2478(97)00126-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199207000-00001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071806"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.8.4.451"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1615\/forumimmundisther.2017020161"},{"key":"9","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.4049\/jimmunol.162.5.2829","article-title":"Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice","volume":"162","author":"M. E. Rottenberg","year":"1999","journal-title":"The Journal of Immunology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.09.071"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00011"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.4148"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.02.010"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2020.02.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12470"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0083"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2004.09.002"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.4040"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)81059-7"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-016-0171-y"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80702-3"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.4.565"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-106831"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80047-1"}],"container-title":["International Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2022\/6082140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2022\/6082140.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2022\/6082140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T17:14:50Z","timestamp":1675358090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijmicro\/2022\/6082140\/"}},"subtitle":[],"editor":[{"given":"Sujata","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":25,"alternative-id":["6082140","6082140"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6082140","relation":{},"ISSN":["1687-9198","1687-918X"],"issn-type":[{"type":"electronic","value":"1687-9198"},{"type":"print","value":"1687-918X"}],"subject":[],"published":{"date-parts":[[2022,4,19]]}}}