{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:28:51Z","timestamp":1793089731920,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2022,7,9]]},"abstract":"<jats:p>Background. Due to the high false negative rate (FNR) associated with sentinel lymph node biopsy (SLNB) after neoadjuvant systemic therapy (NAST), the standard surgical treatment for patients with an initially positive axilla and indicated for NAST is axillary lymph node dissection (ALND). To avoid unnecessary ALND, this multicenter, prospective, observational study aimed to determine the effectiveness and ease of using magnetic seeds (Magseed\u00ae) for targeted axillary dissection (TAD) when the seeds are placed before or after NAST. Materials and Methods. We recruited 81 patients diagnosed with T1-T3 breast cancer, with clinically\/radiologically positive nodal involvement (cN1, 75 patients with 1\u20133 nodes suspected nodes and 6 patients with up to 4 suspected nodes) prior to NAST. Positive nodes detected by fine-needle aspiration biopsy or core needle biopsy were marked with a stainless steel marker coil and after NAST with Magseed\u00ae prior to surgery (Post-NAST group), or directly with Magseed\u00ae before NAST (Pre-NAST group). The correlation between lymph nodes marked with Magseed\u00ae (MLNs) and sentinel lymph nodes (SLNs) was calculated based on pathologic assessment with the OSNA assay (Sysmex Corporation, Kobe) or conventional sectioning and staining techniques according to the standard protocols of each center. Results. All magnetic seeds were successfully identified and retrieved in just over 10 minutes of surgery, guided by the Sentimag\u00ae magnetometer system. The overall concordance rate between MLNs and SLNs was 81.5%, and the concordance between MLNs and SLNs with metastasis was 93.8%. Metastasis was detected in 54.3% of the MLNs compared with 48.1% of SLNs. In cases that presented negative MLN and negative SLN (negative TAD), the FNR was 0%. No significant differences were found between the Post-NAST and Pre-NAST groups. Conclusions. Our results validate the use of Magseed\u00ae for long-term marking of axillary lymph nodes and show that when used in combination with SLNB for TAD, a FNR of 0% can be achieved, avoiding unnecessary ALND.<\/jats:p>","DOI":"10.1155\/2022\/6111907","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T21:20:07Z","timestamp":1657401607000},"page":"1-8","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of Axillary Lymph Node Marking with Magseed\u00ae before and after Neoadjuvant Systemic Therapy in Breast Cancer Patients: MAGNET Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2518-091X","authenticated-orcid":true,"given":"Mar\u00eda","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Radiology Department, Hospital General Universitario Morales Meseguer, Avda. Marq\u00faes de Los V\u00e9lez S\/n, Murcia 30007, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Universitario 12 de Octubre, Av. de C\u00f3rdoba S\/n, Madrid 28041, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-9022","authenticated-orcid":true,"given":"Florentina","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Virgen de La Arrixaca, Ctra. Madrid-Cartagena S\/n, Murcia 30120, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Gynaecology Department, Hospital Universitario Donostia, Begiristain Doktorea Pasealekua, S\/n, Donostia 20014, Gipuzkoa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-6459","authenticated-orcid":true,"given":"Elena","family":"Arizaga","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Universitario Donostia, Begiristain Doktorea Pasealekua, S\/n, Donostia 20014, Gipuzkoa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1694-8632","authenticated-orcid":true,"given":"Consuelo","family":"Sanz","sequence":"additional","affiliation":[{"name":"Gynaecology Department, Hospital Universitario 12 de Octubre, Av. de C\u00f3rdoba, S\/n, Madrid 28041, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9863-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1999.17.1.143"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0960-7404(93)90064-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9025-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000149429.39656.94"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11470"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.02.5023"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278932"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.07.020"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70166-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-00755-7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000000558"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000001375"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.11.013"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170740"},{"key":"16","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.SABCS20-GS1-10","article-title":"Abstract GS1-10: radioactive Iodine Seed placement in the Axilla with Sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer: results of the prospective multicenter RISAS trial","volume":"81","author":"J. Simons","year":"2021","journal-title":"Cancer Research"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.17.18345"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.19.21378"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2021.03.008"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.06.004"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-06-2512"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09542-y"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.55.7827"},{"key":"24","article-title":"Magnetic marker approved for any soft tissue and long-term implantation across europe","author":"S. Magseed\u00ae","year":"2022"},{"key":"25","article-title":"RISAS procedure in node positive breast cancer following nac (risas)","year":"2022"},{"key":"26","article-title":"Magseed enabled long-term localization of axillary lymph nodes (magellan)","year":"2022"}],"container-title":["The Breast Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tbj\/2022\/6111907.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tbj\/2022\/6111907.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tbj\/2022\/6111907.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T21:20:12Z","timestamp":1657401612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/tbj\/2022\/6111907\/"}},"subtitle":[],"editor":[{"given":"Neslihan","family":"Cabioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,9]]},"references-count":26,"alternative-id":["6111907","6111907"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6111907","relation":{},"ISSN":["1524-4741","1075-122X"],"issn-type":[{"value":"1524-4741","type":"electronic"},{"value":"1075-122X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,9]]}}}