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The chloroform fraction of gall extract was subjected to column chromatographic which led to the isolation of compound <jats:bold>1<\/jats:bold>, elucidated to be 5\u2010hydroxy\u20107\u2010methoxy\u20102\u2010(4\u2010methoxyphenyl)\u20104<jats:italic>H<\/jats:italic>\u2010chromen\u20104\u2010one (a flavone). <jats:italic>In vitro<\/jats:italic> and in silico PDE1 inhibitory activity of the compound <jats:bold>1<\/jats:bold> was investigated. EDTA, a known PDE1 inhibitor, was used as the reference. The flavone exhibited <jats:italic>in vitro<\/jats:italic> attenuation towards snake venom PDE1. IC<jats:sub>50<\/jats:sub> response was superior to the standard chelator. An in silico molecular docking study was carried out using 3D structure of PDE1 to study the binding interactions of compound <jats:bold>1.<\/jats:bold> The docking study predicted that flavone had a lower binding affinity (\u20107.6\u2009kcal\/mol) and total energy (\u201095\u2009kcal\/mol) score compared to EDTA. The minimal energy associated with the ligand\u2010protein complex implied that isolated compound 1 can serve as a therapeutic agent against PDE1 enzyme\u2010provoked ailments like asthma, hypertension, schizophrenia, and erectile dysfunction.<\/jats:p>","DOI":"10.1155\/2022\/6116003","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T20:05:07Z","timestamp":1642449907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potent <i>In Vitro<\/i> Phosphodiesterase 1 Inhibition of Flavone Isolated from <i>Pistacia integerrima<\/i> 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