{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:50:31Z","timestamp":1771649431181,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":210,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the mechanism of T cell costimulatory molecules in the cellular immune response of premature mice mediated by intestinal microbiota","award":["1908058MH274"],"award-info":[{"award-number":["1908058MH274"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>To preliminarily understand the differentiation characteristics of regulatory T cells (Tregs) and Th17 at a different time in preterm mice, the impacts of probiotics on immune function progression, as well as the correlation of probiotics with Tregs and Th17. On embryonic day 18 of gestation, a mouse model of preterm birth was built using mifepristone (RU486). Following IPI of RU486, newborn mice were randomized to probiotics or NS gavage administration. Full\u2010term newborn mice were given the same dose of NS gavage administration. Phenotypic analysis of peripheral immune cell frequency was performed using flow cytometry. Cytokine measurements were phenotyped by enzyme\u2010linked immunosorbent assays. On the 14th and 21st days after birth, the highest and lowest expressions of Foxp3, the Treg transcription factor, were observed in full\u2010term mice and premature mice by NS gavage administration, respectively, while the opposite trend was found in the Th17 transcription factor IL\u201017.IL\u20102, IL\u20106, and TGF\u2010<jats:italic>\u03b2<\/jats:italic> rose with age but showed different trends among the three groups. IL\u20102 is the highest in full\u2010term mice and the lowest in premature mice. IL\u20106 and TGF\u2010<jats:italic>\u03b2<\/jats:italic> is the lowest in full\u2010term mice and the highest in premature mice. Probiotics are beneficial to the development and maturation of the immune system, which may play a role in regulating the ratio of Treg\/Th17. Probiotic preintervention can effectively promote the differentiation of Treg and inhibit the differentiation of Th17 in premature mice. Its mechanism of action may play a biological role by regulating cytokine (IL\u20102, IL\u20106, and TGF\u2010<jats:italic>\u03b2<\/jats:italic>) secretions.<\/jats:p>","DOI":"10.1155\/2022\/6131069","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T22:05:09Z","timestamp":1659218709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["[Retracted] Effect of Intervention of Probiotics in Advance on Treg\/Th17 in Premature Mice"],"prefix":"10.1155","volume":"2022","author":[{"given":"Mengmeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8102-1318","authenticated-orcid":false,"given":"Shifa","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"1","article-title":"Births: final data for 2018","volume":"68","author":"Martin J. A.","year":"2019","journal-title":"National vital statistics reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System"},{"key":"e_1_2_9_2_2","first-page":"3","article-title":"The global epidemiology of preterm birth. Best practice & research","volume":"52","author":"Vogel J. P.","year":"2018","journal-title":"Clinical Obstetrics & Gynaecology"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61577-8"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.2196"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00796-10"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.27"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00733-8"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.12.004"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010134"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0004-4"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03012"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030730"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1311318"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00079"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141623"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1549"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3464"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-5-12"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01714-09"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b06177"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02942.x"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1603758"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040782"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07036"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-500"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.1.65"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1497"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.02.009"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2030"}],"updated-by":[{"DOI":"10.1155\/2023\/9859531","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"record-id":"60559"},{"DOI":"10.1155\/2023\/9859531","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6131069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6131069.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/6131069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T20:29:19Z","timestamp":1735676959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/6131069"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/6131069"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6131069","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9859531","asserted-by":"object"}]},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6131069"}}