{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:56:06Z","timestamp":1791946566908,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,4,13]]},"abstract":"<jats:p>Objective. The focus of this study was to evaluate the gastric healing effect of lupeol stearate (LS) and its ability to minimize ulcer recurrence in rodents. Methods. To evaluate the gastric healing properties of LS, rats were subjected to 80% acetic acid-induced ulcer model and treated with vehicle, LS (1\u2009mg\/kg, p.o.), or omeprazole (20\u2009mg\/kg, p.o.), twice daily by seven days. The gastric ulcers were evaluated macroscopically, histologically, and biochemically. To evaluate the effects of LS in gastric ulcer recurrence, mice were ulcerated with 10% acetic acid and treated with vehicle, LS (1\u2009mg\/kg, p.o.), or ranitidine (100\u2009mg\/kg, p.o.), twice a day for ten days. Then, ulcer recurrence in these animals was induced by IL-1\u03b2 at five days after the treatment period. Results. The oral treatment with LS accelerated gastric healing by 63% in rats compared to the vehicle group, evidenced by histological improvement and increased gastric mucin levels. Moreover, the gastric healing effects of LS in rats were accompanied by an elevation in glutathione S-transferase activity and a reduction in myeloperoxidase activity. Furthermore, the LS treatment reduced the recurred lesions in mice. Conclusions. The oral treatment of LS accelerates gastric healing in rats by favoring mucus production and reducing neutrophil migration, and it also can reduce ulcer recurrence. These data highlighted this compound as promising for developing new pharmacological strategies for the management of gastric ulcer.<\/jats:p>","DOI":"10.1155\/2022\/6134128","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T18:50:06Z","timestamp":1649875806000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents"],"prefix":"10.1155","volume":"2022","author":[{"given":"Lincon Bordignon","family":"Somensi","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Sociedade (PPGDS), Universidade Alto Vale do Rio do Peixe, CEP, 89500-199 Ca\u00e7ador, SC, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas (PPGCF), N\u00facleo de Investigac\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), Rua Uruguai, 458, 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