{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:24:53Z","timestamp":1755926693906,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,7,30]]},"abstract":"<jats:p>This work is aimed at exploring the mechanism of inflammatory factors and soluble vascular cell adhesion molecule-1 (sVCAM-1) regulated by nuclear transcription factor-\u03baB (NF-\u03baB) in unstable angina pectoris (UAP). 60 patients with unstable angina pectoris (UAP), 60 patients with stable angina pectoris (SAP), and some healthy people (controls) were selected and included. Peripheral venous blood (PVB) of all subjects was collected to detect blood routine. The enzyme-linked immunosorbent assay (ELISA) was adopted for detecting Visfatin, sVCAM-1, soluble intervascular cell adhesion molecule-1 (sICAM-1), and inflammatory factors; flow cytometry (FCM) was to detect the CD63 and CD62P; real-time fluorescence quantitative polymerase chain reaction (rt-qPCR) was employed to detect the NF-\u03baB1, NF-\u03baB2, and REL mRNA. The hs-CRP results of UAP group, SAP group, and control group were <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>11.12<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>1.5<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009mg\/L, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mn>10.23<\/c:mn>\n                        <c:mo>\u00b1<\/c:mo>\n                        <c:mn>1.3<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009mg\/L, and <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mn>4.51<\/e:mn>\n                        <e:mo>\u00b1<\/e:mo>\n                        <e:mn>1.1<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009mg\/L, respectively. The CD62P results of UAP group, SAP group, and control group were <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>16.07<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>2.5<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>%, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mn>11.09<\/i:mn>\n                        <i:mo>\u00b1<\/i:mo>\n                        <i:mn>1.8<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>%, and <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mn>22.15<\/k:mn>\n                        <k:mo>\u00b1<\/k:mo>\n                        <k:mn>0.4<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>%, respectively. The high-sensitivity C-reactive protein (hs-CRP), inflammatory factors (IL-6, IL-17, IL-23, IL-1\u03b2, and tumor necrosis factor \u03b1 (TNF-\u03b1)), CD63, CD62P, NF-\u03baB1, NF-\u03baB2, and REL mRNA were obviously higher in the SAP group compared than the indicator values in the control group (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.05<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). The relative REL expression results of UAP group, SAP group, and control group were <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mn>3.77<\/o:mn>\n                        <o:mo>\u00b1<\/o:mo>\n                        <o:mn>1.5<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mn>2.2<\/q:mn>\n                        <q:mo>\u00b1<\/q:mo>\n                        <q:mn>0.6<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>, and <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mn>1<\/s:mn>\n                        <s:mo>\u00b1<\/s:mo>\n                        <s:mn>0.4<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>, respectively. The inflammatory factors, Visfatin, sVCAM-1, sICAM-1, CD63, CD62P, NF-\u03baB1, NF-\u03baB2, and REL mRNA in the UAP group showed higher levels in contrast to the other two groups (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>P<\/u:mi>\n                        <u:mo>&lt;<\/u:mo>\n                        <u:mn>0.05<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>). In summary, UAP patients had marked activation of the IL-23\/IL-17 inflammatory axis, high expressions of sVCAM-1 and sICAM-1, and activation of the NF-\u03baB pathway. Increase of inflammatory factors and sVCAM-1 regulated by NF-\u03baB was closely correlated with UAP.<\/jats:p>","DOI":"10.1155\/2022\/6137219","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T02:20:10Z","timestamp":1659234010000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["The Mechanism of Inflammatory Factors and Soluble Vascular Cell Adhesion Molecule-1 Regulated by Nuclear Transcription Factor NF-\u03baB in Unstable Angina Pectoris"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-7590","authenticated-orcid":true,"given":"Qingfeng","family":"Su","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanxi Provincial People\u2019s Hospital, Taiyuan, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanxi Provincial People\u2019s Hospital, Taiyuan, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhui","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanxi Provincial People\u2019s Hospital, Taiyuan, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Shanxi Provincial People\u2019s Hospital, Taiyuan, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm.2019.01.53"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2020.100655"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.1\/mdehert"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5578\/turkjsurg.4165"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021593"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00213"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12736"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154836"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.4.16"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12959"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2017.07.007"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11071134"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-017-0919-x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02031"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0000000000000419"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.36740\/WLek202003132"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0171-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-1001"},{"issue":"20","key":"19","first-page":"4642","article-title":"Effects of remote ischemic preconditioning on myocardial injury and endothelial function and prognosis after percutaneous coronary intervention in patients with acute coronary syndrome","volume":"21","author":"F. Z. Zhou","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.233953"},{"issue":"1","key":"21","first-page":"31","article-title":"Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris","volume":"21","author":"Z. R. Luo","year":"2001","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.24"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-018-1885-z"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1159\/000490866"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900083"},{"issue":"4","key":"26","first-page":"551","article-title":"Effect of NF-kB signaling pathway on the expression of MIF, TNF-\u03b1, IL-6 in the regulation of intervertebral disc degeneration","volume":"18","author":"H. Liang","year":"2018","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12871"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/6137219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/6137219.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/6137219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T02:20:14Z","timestamp":1659234014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2022\/6137219\/"}},"subtitle":[],"editor":[{"given":"Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,30]]},"references-count":27,"alternative-id":["6137219","6137219"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6137219","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"type":"electronic","value":"2314-7156"},{"type":"print","value":"2314-8861"}],"subject":[],"published":{"date-parts":[[2022,7,30]]}}}