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Computation intelligence is the study of design of intelligent agents which are systems acting perceptively. The computation intelligence paradigm offers more advantages to the enhancement and maintenance of the field of biomedical engineering. Liver cancer is the major reason of mortality worldwide. Earlier-stage diagnosis and treatment might increase the survival rate of liver cancer patients. Manual recognition of the cancer tissue is a time-consuming and difficult task. Hence, a computer-aided diagnosis (CAD) is employed in decision making procedures for accurate diagnosis and effective treatment. In contrast to classical image-dependent \u201csemantic\u201d feature evaluation from human expertise, deep learning techniques could learn feature representation automatically from sample images using convolutional neural network (CNN). This study introduces a Hybrid Rider Optimization with Deep Learning Driven Biomedical Liver Cancer Detection and Classification (HRO-DLBLCC) model. The proposed HRO-DLBLCC model majorly focuses on the identification of liver cancer in the medical images. To do so, the proposed HRO-DLBLCC model employs preprocessing in two stages, namely, Gabor filtering (GF) based noise removal and watershed transform based segmentation. In addition, the proposed HRO-DLBLCC model involves NAdam optimizer with DenseNet-201 based feature extractor to generate an optimal set of feature vectors. Finally, the HRO algorithm with recurrent neural network\u2013long short-term memory (RNN-LSTM) model is applied for liver cancer classification, in which the hyperparameters of the RNN-LSTM model are tuned by the use of HRO algorithm. The HRO-DLBLCC model is experimentally validated and compared with existing models. The experimental results assured the promising performance of the HRO-DLBLCC model over recent approaches.<\/jats:p>","DOI":"10.1155\/2022\/6162445","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T16:35:15Z","timestamp":1656606915000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Hybrid Rider Optimization with Deep Learning Driven Biomedical Liver Cancer Detection and Classification"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-271X","authenticated-orcid":true,"given":"Mesfer","family":"Al Duhayyim","sequence":"first","affiliation":[{"name":"Department of Computer Science, College of Sciences and Humanities-Aflaj, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan Abdullah","family":"Mengash","sequence":"additional","affiliation":[{"name":"Department of Information Systems, College of Computer and Information Sciences, Princess Nourah Bint Abdulrahman University, P.O. 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