{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:35:09Z","timestamp":1758040509178,"version":"3.44.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":284,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005771","name":"Dokuz Eyl\u00fcl \u00dcniversitesi","doi-asserted-by":"publisher","award":["2017.KB.SAG.009"],"award-info":[{"award-number":["2017.KB.SAG.009"]}],"id":[{"id":"10.13039\/501100005771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. This study aims to evaluate the effects of bevacizumab and propranolol from the point of view of a possible antiangiogenic effect in a model of primary nasal polyp (NP) tissue culture. <jats:italic>Methods<\/jats:italic>. NP samples of 21 patients and normal healthy nasal mucosa samples of 7 patients were cultured. Samples were divided into four groups as follows (healthy nasal mucosa, NP without any treatment, NP treated with propranolol, NP treated with bevacizumab). Cultured tissues were formalin fixed and paraffin embedded. Tissue sections and immunohistochemical VEGF\u2010A, angiopoietin\u20101 (Ang\u20101), and angiopoietin\u20102 (Ang\u20102) expressions were evaluated. ELISA was also performed for each one of them. <jats:italic>Results<\/jats:italic>. Both propranolol and bevacizumab significantly decreased the expressions of VEGF\u2010A and Ang\u20101, and they significantly increased the expression of Ang\u20102 in comparison to the control NP group. In the healthy nasal mucosa group, no significant expression of VEGF\u2010A was seen, a slight (+) Ang\u20101 expression, and a high (+++) Ang\u20102 expression were observed. <jats:italic>Conclusion<\/jats:italic>. Bevacizumab and propranolol exert an antiangiogenic effect on NP tissues, mainly by decreasing VEGF\u2010A and Ang\u20101 expression, increasing Ang\u20102 expression.<\/jats:p>","DOI":"10.1155\/2022\/6174664","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T18:20:46Z","timestamp":1665598846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Bevacizumab and Propranolol on Nasal 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