{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:21:45Z","timestamp":1767165705099,"version":"build-2238731810"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":254,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30083"],"award-info":[{"award-number":["2022JJ30083"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . The effects of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 on mechanical properties of sclerotic desmocytes isolated from healthy and myopic guinea pigs were investigated in order to further understand the pathogenesis of myopia. To study the effect of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 on the mechanical properties of posterior scleral fibroblasts in experimental myopia.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A lens\u2010induced myopia (LIM) animal model was developed in 12 guinea pigs, with the opposite eye serving as a self\u2010control (SC). Five untreated guinea pigs served as normal controls. Lenses were removed 30 days after model onset. Primary scleral fibroblasts were isolated and passaged twice and then treated with vehicle control or 1, 10, or 100\u2009ng\/mL TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2. After 24\u2009h, micropipette aspiration was used to investigate the viscoelastic properties of the cells.\n                    <jats:italic>Results<\/jats:italic>\n                    . Scleral fibroblasts from LIM exhibited significantly higher equilibrium moduli and apparent viscosities relative to SC without TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 treatment. Treatment of LIM or SC scleral fibroblasts with 1 or 10\u2009ng\/mL TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 led to significantly different (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) equilibrium moduli and apparent viscosities compared with vehicle control, whereas no significant differences were observed upon treatment with 100\u2009ng\/mL TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2. LIM cells treated with 1 and 10\u2009ng\/mL TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 exhibited lower equilibrium moduli and apparent viscosities compared with similarly treated SC cells, but LIM cells and SC cells treated with 100\u2009ng\/mL TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 had similar mechanical properties.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . The addition of 1 and 10\u2009ng\/mL TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2 can lower the equilibrium modulus and apparent viscosity of scleral fibroblasts in the normal eye.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6193876","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T23:20:15Z","timestamp":1663024815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["[Retracted] Effect of TGF\u2010\u03b22 on the Mechanical Properties of Posterior Scleral Fibroblasts in Experimental Myopia"],"prefix":"10.1155","volume":"2022","author":[{"given":"Boyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoyan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-7001","authenticated-orcid":false,"given":"Jingxue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"391","article-title":"Effects of concave lens on eyes of guinea pig","volume":"20","author":"Ouyang C.","year":"2002","journal-title":"Chinese Ophthalmic Research"},{"key":"e_1_2_9_2_2","first-page":"113","article-title":"Scleral biomechanical properties in high myopia","volume":"21","author":"Wang C.","year":"2003","journal-title":"Chinese Ophthalmic Research"},{"key":"e_1_2_9_3_2","first-page":"209","article-title":"A biomechanical study of the sclera in experimental myopia","volume":"8","author":"Sun Z.","year":"2006","journal-title":"Chinese Journal of Optometry & Ophthalmology"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1854-y"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1049"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781003210351-8"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1201\/9780429276064-12"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2003.10.007"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.10.004"},{"key":"e_1_2_9_10_2","first-page":"197","article-title":"Role of RPE choroid axis on the occurrence of myopia","volume":"2","author":"Ning H. 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KARE: a hybrid reasoning approach for promoting active lifestyle Proceedings of the 9th International Conference on Ubiquitous Information Management and Communication January 2015 Bali Indonesia 1\u20135.","DOI":"10.1145\/2701126.2701156"}],"updated-by":[{"DOI":"10.1155\/2023\/9815373","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"record-id":"58004"},{"DOI":"10.1155\/2023\/9815373","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6193876.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6193876.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/6193876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T11:05:05Z","timestamp":1735643105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/6193876"}},"subtitle":[],"editor":[{"given":"Zhijun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/6193876"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6193876","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6193876"}}