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Colchicine is a strong anti\u2010inflammatory drug used to prevent and treat acute gout and treat familial Mediterranean fever. And also, its protective effects on cardiovascular disease have been reported in various studies. The current study is aimed at appraising the effect of colchicine on 5\u2010fluorouracil\u2010induced cardiotoxicity in rats. <jats:italic>Methods<\/jats:italic>. Twenty male Wistar rats were divided into four groups as follows: control, 5\u2010fluorouracil, colchicine (5\u2009mg\/kg), and 5\u2010fluorouracil+5\u2009mg\/kg colchicine. Cardiotoxicity was induced with an intraperitoneal injection of a single dose of 5\u2010fluorouracil (100\u2009mg\/kg). The control group received normal saline, and the treatment groups received colchicine with an intraperitoneal injection for 14 days. <jats:italic>Findings<\/jats:italic>. 5\u2010Fluorouracil resulted in significant cardiotoxicity represented by an increase in cardiac enzymes, malondialdehyde levels, cyclooxygenase\u20102 and tumor necrosis factor\u2010alpha expression, cardiac enzymes, and histopathological degenerations. 5\u2010Fluorouracil treatment also decreased body weight, total antioxidant capacity and catalase values, blood cells, and hemoglobin levels. In addition, 5\u2010fluorouracil disrupted electrocardiographic parameters, including increased elevation in the ST segment and increased QRS duration. Treatment with colchicine reduced oxidative stress, cardiac enzymes, histopathological degenerations, and cyclooxygenase\u20102 expression in cardiac tissue, improved electrocardiographic disorders, and enhanced the number of blood cells and total antioxidant capacity levels. Moreover, body weight loss was hampered after treatment with colchicine. Our results demonstrated that treatment with colchicine significantly improved cardiotoxicity induced by 5\u2010fluorouracil in rats.<\/jats:p>","DOI":"10.1155\/2022\/6194532","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T17:05:08Z","timestamp":1643389508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Colchicine Ameliorates 5\u2010Fluorouracil\u2010Induced Cardiotoxicity in 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