{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:55:39Z","timestamp":1767167739494,"version":"build-2238731810"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":168,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1705003"],"award-info":[{"award-number":["2018YFC1705003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["Z200016"],"award-info":[{"award-number":["Z200016"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Limited data were available about the combined impact of systolic blood pressure (SBP) and low\u2010density lipoprotein cholesterol (LDL\u2010C) levels on intracerebral hemorrhage (ICH) prognosis. The objective of this study is to explore whether the relationship between LDL\u2010C and ICH outcomes was modified by SBP levels in a Chinese population. From August 1, 2015, to July 31, 2019, 75,443 ICH patients enrolled from the Chinese Stroke Center Alliance program were included in our study. Patients were divided into LDL\u2010C levels of &lt;70\u2009mg\/dL, 70\u2010100\u2009mg\/dL, and \u2265100\u2009mmol\/L. SBP was stratified as &lt;140\u2009mmHg, 140\u2010180\u2009mmHg, and \u2265180\u2009mmHg. The primary outcome was the occurrence of hematoma expansion (HE), and the second outcome was in\u2010hospital mortality. Correlation between LDL\u2010C levels and SBP on ICH outcomes were assessed by logistic regression. 6,116 (8.1%) and 1,576 (2.1%) patients suffered HE and in\u2010hospital mortality. Compared with the \u2265100\u2009mg\/dL group, patients with LDL\u2010C concentrations under 70\u2009mg\/dL had a 19% and 24% increase in the relative risk of HE (crude OR 1.19, 95% CI 1.11\u20101.28) and in\u2010hospital mortality (crude OR 1.24, 95% CI 1.08\u20101.42). When SBP was added as a stratification variable, the above\u2010mentioned association was attenuated in patients under a threshold SBP of 140\u2009mmHg (\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0.05). However, no statistical interaction was detected between SBP and LDL\u2010C levels. Lower LDL\u2010C levels (&lt;70\u2009mg\/dL) are related to a higher risk of HE and in\u2010hospital mortality confined to ICH patients with elevated SBP (\u2265140\u2009mmHg).\n                  <\/jats:p>","DOI":"10.1155\/2022\/6206315","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T14:50:08Z","timestamp":1655563808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[Retracted] Combined Association of Low\u2010Density Lipoprotein Cholesterol Levels and Systolic Blood Pressure to the Outcome of Intracerebral Hemorrhage: Data from the China Stroke Center 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