{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:49:19Z","timestamp":1747190959501,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2022,3,22]]},"abstract":"<jats:p>Introduction. Recurrent extreme hyperferritinemia (ferritin &gt;10,000\u2009ng\/mL) was noted in 4 critically ill adolescents prior to death, though this association has not previously been described. Methods. A retrospective review of the medical records of 4 critically ill adolescents with recurrent extreme hyperferritinemia and systemic inflammation was performed to identify additional common epidemiologic factors. Results. Systemic inflammation was characterized as cytokine storm syndrome in 2 patients and hemophagocytic lymphohistiocytosis in 2 patients. Episodes of extreme hyperferritinemia were noted on at least 2 different dates in all patients; these episodes (n\u2009=\u200910) were separated by an interval of 2 weeks to several months and were usually (in 8 of 10 episodes) associated with the onset or worsening of multiple organ dysfunction syndrome. Death occurred within 2 weeks of the onset of an episode of recurrent extreme hyperferritinemia. Lymphocytopenia and cachexia were noted in all patients. Conclusions. Recurrent extreme hyperferritinemia\u2014often with multiple organ dysfunction syndrome\u2014was noted in 4 adolescents with systemic inflammation who did not survive their critical illness. Recurrent extreme hyperferritinemia may be a novel biomarker of increased mortality in patients with the syndrome of persistent inflammation, immunosuppression, and catabolism.<\/jats:p>","DOI":"10.1155\/2022\/6207417","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T23:05:05Z","timestamp":1647990305000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-5142","authenticated-orcid":true,"given":"John Scott","family":"Baird","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0b013e31820abca8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-201090"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21423"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000002074"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra2026131"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)13908-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2012-2"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx031"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-253815"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01511"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.s331411"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00369-w"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017012310"}],"container-title":["International Journal of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2022\/6207417.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2022\/6207417.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/iji\/2022\/6207417.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T23:05:07Z","timestamp":1647990307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/iji\/2022\/6207417\/"}},"subtitle":[],"editor":[{"given":"Istvan","family":"Boldogh","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":15,"alternative-id":["6207417","6207417"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6207417","relation":{},"ISSN":["2042-0099","2090-8040"],"issn-type":[{"type":"electronic","value":"2042-0099"},{"type":"print","value":"2090-8040"}],"subject":[],"published":{"date-parts":[[2022,3,22]]}}}