{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:32:25Z","timestamp":1793932345288,"version":"4.8.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Haikou Maternal and Child Health Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:p>Objective. To explore the efficacy and safety of Saccharomyces boulardii for the treatment of acute gastroenteritis in children aged under 5. Methods. Two independent researchers retrieved literature from PubMed, OVID, Embase, ScienceDirect, and other databases, followed by extracting indicators of the primary endpoints. Cochrane Q test and<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:msup><a:mrow><a:mi>I<\/a:mi><\/a:mrow><a:mrow><a:mn>2<\/a:mn><\/a:mrow><\/a:msup><\/a:math><\/jats:inline-formula>statistics were used to evaluate interstudy heterogeneity. The relative risk (RR) and mean difference (MD) of related indicators were calculated and combined using the random- or fixed-effect model, as appropriate. Furthermore, the funnel plot and Egger\u2019s test were used to evaluate the publication bias. A two-sided<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><c:mo>&lt;<\/c:mo><c:mn>0.05<\/c:mn><\/c:math><\/jats:inline-formula>denoted statistical significance. Results. 10 articles were included in this meta-analysis, with a total of 1282 children having acute gastroenteritis. The use of Saccharomyces boulardii in children with acute gastroenteritis could effectively shorten diarrhea duration (<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mtext>MD<\/e:mtext><e:mo>=<\/e:mo><e:mn>19.70<\/e:mn><\/e:math><\/jats:inline-formula>, 95% CI: -24.87, 14.52) and reduce the length of hospital stay (<jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mtext>MD<\/g:mtext><g:mo>=<\/g:mo><g:mo>\u2212<\/g:mo><g:mn>0.91<\/g:mn><\/g:math><\/jats:inline-formula>, 95% CI: -1.28, -0.54). Compared with the control group, the RR of continued diarrhea was significantly lower in the treatment group after 1 day treatment (<jats:inline-formula><i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><i:mtext>RR<\/i:mtext><i:mo>=<\/i:mo><i:mo>\u2212<\/i:mo><i:mn>0.31<\/i:mn><\/i:math><\/jats:inline-formula>, 95% CI: 0.59, 0.03) and 3 days treatment (<jats:inline-formula><k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><k:mtext>RR<\/k:mtext><k:mo>=<\/k:mo><k:mn>0.52<\/k:mn><\/k:math><\/jats:inline-formula>, 95% CI: 0.41, 0.66). In addition, treatment with Saccharomyces boulardii reduced the average number of diarrhea after 3 days of treatment by about 1.03 (<jats:inline-formula><m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><m:mtext>MD<\/m:mtext><m:mo>=<\/m:mo><m:mo>\u2212<\/m:mo><m:mn>1.03<\/m:mn><\/m:math><\/jats:inline-formula>, 95% CI: -1.53, -0.53). There were no adverse drug reactions in both groups. Conclusion. The use of probiotic Saccharomyces boulardii can significantly improve the symptoms of diarrhea in children with acute gastroenteritis and reduce the duration of diarrhea symptoms and the time of hospitalization. Meanwhile, the RR of continued diarrhea in children after 1 and 3 days of Saccharomyces boulardii treatment and the frequency of diarrhea after 3 days of Saccharomyces boulardii treatment were decreased. It is also safe and does not increase the incidence of adverse drug reactions.<\/jats:p>","DOI":"10.1155\/2022\/6234858","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T01:20:08Z","timestamp":1663723208000},"page":"1-10","source":"Crossref","is-referenced-by-count":17,"title":["Effectiveness and Safety of Saccharomyces Boulardii for the Treatment of Acute Gastroenteritis in the Pediatric Population: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2022","author":[{"given":"Hongbo","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Emergency, Haikou Maternal and Child Health Hospital, Haikou 570203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Haikou Hospital of Traditional Chinese Medicine, Haikou 570216, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Haikou Maternal and Child Health Hospital, Haikou 570203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihuai","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Emergency, Haikou Maternal and Child Health Hospital, Haikou 570203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-3543","authenticated-orcid":true,"given":"Yajuan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wenchang City People's Hospital, Wenchang 571300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39036.406169.80"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02849868"},{"key":"3","article-title":"Managing acute gastroenteritis among children","volume":"52","author":"J. 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