{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:07:50Z","timestamp":1777302470049,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":121,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009232","name":"Debreceni Egyetem","doi-asserted-by":"publisher","award":["EFOP-3.6.3-VEKOP-16-2017-00009"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00009"]}],"id":[{"id":"10.13039\/501100009232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Overlap myositis is a distinct subgroup of idiopathic inflammatory myositis (IIM) with various clinical phenotypes. The aim of this study was to determine the clinical, serological, and genetic features of systemic sclerosis (SSc)\u2010IIM overlap patients. It was a retrospective study using clinical database of 39 patients, fulfilling both the criteria of SSc and IIM. 56.4% of the patients had limited cutaneous, 43.6% had diffuse cutaneous SSc, whereas 7.7% of the patients had dermatomyositis and 92.3% polymyositis. The two diseases occurred simultaneously in 58.97%, while 10.26% in myositis and 30.77% in scleroderma were initially diagnosed. The frequencies of organ involvement were interstitial lung disease 71.8%, dysphagia 66.7%, cardiac involvement 41%, pulmonary arterial hypertension (PAH) 30.8%, and renal involvement 12.8%, respectively. The presence of human leukocyte antigen (HLA) \u2212 DRB1\u221703 and DQA1\u2217051\u221701 alleles were significantly higher in the overlap patients than in healthy controls (82.35% vs. 27.54%; <jats:italic>p<\/jats:italic> &lt; 0.0001 and 88.24% vs. 30.16; <jats:italic>p<\/jats:italic> &lt; 0.0001). Certain clinical parameters, such as fever at diagnosis (41.67% vs. 7.41%, <jats:italic>p<\/jats:italic> = 0.0046), cardiac involvement (83.33% vs. 22.22%, <jats:italic>p<\/jats:italic> = 0.0008), subcutaneous calcinosis (41.66 vs. 11.11, <jats:italic>p<\/jats:italic> = 0.01146), and claw hand deformity (25% vs. 11.11%, <jats:italic>p<\/jats:italic> = 0.00016) were significantly associated with the presence of PAH. Upon comparison, the overlap patients and anti\u2010Jo\u20101 positive antisynthetase patients showed similarities in terms of genetic results and major clinical features; however, SSc\u2010IIM overlap patients could be distinguished with higher erythrocyte sedimentation rate (ESR) level, more frequent presence of Raynaud\u2019s phenomenon (<jats:italic>p<\/jats:italic> &lt; 0.0001; OR: 20.00), dysphagia (<jats:italic>p<\/jats:italic> &lt; 0.0001; OR: 15.63), and infrequent livedo reticularis (<jats:italic>p<\/jats:italic> &lt; 0.01; OR: 0.11). SSc\u2010IIM overlap myositis is a unique group within IIM\u2010s possessing characteristic clinical features.<\/jats:p>","DOI":"10.1155\/2022\/6251232","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T15:51:24Z","timestamp":1651506684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical, Serological, and Genetic Characteristics of a Hungarian Myositis\u2010Scleroderma Overlap 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