{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:57:18Z","timestamp":1792803438962,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":284,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Administration of Traditional Chinese Medicine","award":["2021B108"],"award-info":[{"award-number":["2021B108"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background and Objective<\/jats:italic>. To explore the effect of miR\u2010124\u20103p delivered by exosomes on psoriatic keratinocytes stimulated by IL\u201017A. <jats:italic>Methods<\/jats:italic>. NHEKs, HaCaT cells, and HEK 293T cells were treated with IL\u201017A. CCK\u20108 assays were performed to detect cell activity, and immunofluorescence staining and Western blotting were performed to detect the protein expression of STAT3. After isolation of exosomes via ultracentrifugation, the contents of miR\u2010124\u20103p and oxidative stress markers such as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH\u2010Px) in keratinocytes were measured. Subsequently, transcriptomic analysis was performed using RNA\u2010seq. Data were analysed by using the \u201cedgeR\u201d package within R. After verifying the abnormally expressed genes stimulated by IL\u201017A, a dual luciferase reporter assay was used to determine the interaction between miR\u2010124\u20103p and STAT3. Finally, BALB\/c mice were used to establish a psoriasis model for analysis. The effect of elevated miR\u2010124\u20103p on the psoriasis mouse model was determined by exosomal delivery of miR\u2010124\u20103p. <jats:italic>Results<\/jats:italic>. IL\u201017 intervention enhanced the cell activity of keratinocytes (<jats:italic>P<\/jats:italic> &lt; 0.05). miR\u2010124\u20103p was identified by RNA\u2010seq as one of the differentially expressed miRNAs stimulated by IL\u201017A. miR\u2010124\u20103p overexpression induced decreased STAT3 and MDA levels, increased SOD and GSH\u2010Px levels in keratinocytes, and alleviated emergency responses of sclerosis damage (<jats:italic>P<\/jats:italic> &lt; 0.05). The dual luciferase reporter assay results confirmed that STAT3 was regulated by miR\u2010124\u20103p in a targeted manner (<jats:italic>P<\/jats:italic> &lt; 0.05). Finally, miR\u2010124\u20103p delivered by exosomes effectively alleviated the pathological manifestations and oxidative stress responses of psoriatic mice. <jats:italic>Conclusions<\/jats:italic>. miR\u2010124\u20103p regulates keratinocyte activity via STAT3 in response to IL\u201017A stimulation. The ectopic expression of miR\u2010124\u20103p in psoriatic skin reduces IL\u201017A\u2010induced inflammation and inhibits the STAT3 pathway, thus alleviating the symptoms of psoriasis. The findings of this study suggest that exosomes can be used to therapeutically deliver miR\u2010124\u20103p to keratinocytes and psoriatic lesions, which may provide novel insight for psoriasis treatment.<\/jats:p>","DOI":"10.1155\/2022\/6264474","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T20:50:10Z","timestamp":1665607810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["[Retracted] miR\u2010124\u20103p Delivered Using Exosomes Attenuates the Keratinocyte Response to IL\u201017A Stimulation in Psoriasis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-8974","authenticated-orcid":false,"given":"Simin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2103"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.139"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.058"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.02.001"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00402"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.045757.114"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0666"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14497"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0134"},{"key":"e_1_2_11_12_2","first-page":"161","article-title":"The role of microRNAs in human diseases","volume":"2","author":"Ardekani A. 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