{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T05:40:08Z","timestamp":1772343608126,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Henan Science and Technology Development Plan","award":["182102311209"],"award-info":[{"award-number":["182102311209"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,11,21]]},"abstract":"<jats:p>Background. To explore clinical characteristics and treatment reasons for intravitreal injection of antivascular endothelial growth factor (anti-VEGF) drugs in the treatment of nontype 1 retinopathy of prematurity (ROP). Methods. A retrospective study was conducted to screen the nontype 1 ROP from the collected ROP patients who received intravitreal injections of anti-VEGF drugs in Henan Eye Hospital from September 2018 to June 2021. Results. A total of 138 ROP cases (262 eyes) were included in this study, including 39 cases (28.3%), 65 eyes (24.8%) that were the nontype 1 ROP. Compared with the type 1 ROP group, the nontype 1 ROP group had slightly later treatment time (39.8\u2009\u00b1\u20092.7 weeks vs 38.1\u2009\u00b1\u20092.6 weeks, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and a higher proportion of fusion protein drugs (87.2% vs 54.5%, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). After intravitreal injection of anti-VEGF drugs, 27 eyes (41.5%) were cured and 38 eyes (58.5%) improved in the nontype 1 ROP group, without recurrence and aggravation cases. There were more lesions in zone II (63 eyes, 96.9%), with stage 2 (40 eyes, 61.5%) and stage 3 (23 eyes, 35.4%), and 58 eyes (89.2%) showed preplus in the nontype 1 ROP group. Treatment reasons included preplus in 58 eyes (89.2%), ridge aggravation in 22 eyes (33.8%), simultaneous treatment of the contralateral eye in 9 eyes (13.8%), no regression of lesions in the persistent stage 2 or 3 over PMA 44 weeks of follow-up in 8 eyes (12.3%), and logistical considerations in 4 eyes (6.2%). Conclusions. Considering some peculiar clinical characteristics, treatment by intravitreal injection of anti-VEGF drugs may be considered carefully for some nontype 1 ROP in critical conditions.<\/jats:p>","DOI":"10.1155\/2022\/6266528","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T20:35:08Z","timestamp":1669062908000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["Treatment for Nontype 1 Retinopathy of Prematurity by Intravitreal Injection of Antivascular Endothelial Growth Factor Drugs"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-429X","authenticated-orcid":true,"given":"Haitao","family":"Zhang","sequence":"first","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, People\u2019s Hospital of Zhengzhou University, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-5366","authenticated-orcid":true,"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, People\u2019s Hospital of Zhengzhou University, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit of Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangke","family":"Yin","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, People\u2019s Hospital of Zhengzhou University, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhua","family":"Wan","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, People\u2019s Hospital of Zhengzhou University, Zhengzhou 450003, 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