{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:00:39Z","timestamp":1774461639216,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,3,20]]},"abstract":"<jats:p>Objective. Sufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective mechanism of sufentanil on rat myocardial ischemia-reperfusion (I\/R) injury. Methods. A rat I\/R model was established by ligating the left anterior descending coronary artery. A total of 24 SD male rats were enrolled and divided randomly into the control group, I\/R group, sufentanil group (SUF; 3\u2009\u03bcg\/kg), and diltiazem group (DLZ; 20\u2009mg\/kg; positive control). The rat hearts were subjected to 30\u2009min of ischemia followed by 120\u2009min of reperfusion. Subsequently, hemodynamics, pathological changes of myocardial tissue, serum biochemical parameters, oxidative stress factors, the level of serum inducible nitric oxide synthases (iNOS), interleukin-6 (IL-6), and other bioactive factors were analyzed in the rats. Result. Compared with the I\/R group, sufentanil significantly improved cardiac action, myocardial fiber, and cardiomyocyte morphology and reduced inflammatory cell infiltration in rats in the SUF group. And the level of creatine kinase isoenzyme (CK-MB), troponin (cTn), lactate dehydrogenase (LDH), malondialdehyde (MDA), iNOS, and IL-6 was significantly declined in the serum of SUF group, while the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly activated in the myocardial tissues. In addition, sufentanil also significantly decreased the protein expression of GRP78, CHOP, Caspase 12, and ATF6 in the myocardial tissue of the SUF group. Conclusion. Sufentanil has a significant protective activity on myocardial I\/R injury in rats, the mechanism of which may be associated with the inhibition of endoplasmic reticulum stress and oxidative stress.<\/jats:p>","DOI":"10.1155\/2022\/6267720","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T22:35:14Z","timestamp":1647815714000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Protective Effect of Sufentanil on Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting Endoplasmic Reticulum Stress"],"prefix":"10.1155","volume":"2022","author":[{"given":"Liuji","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Huizhou Central People\u2019s Hospital, Huizhou, Guangdong 516001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochen","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huizhou Central People\u2019s Hospital, Huizhou, Guangdong 516001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqi","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huizhou Central People\u2019s Hospital, Huizhou, Guangdong 516001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huizhou Central People\u2019s Hospital, Huizhou, Guangdong 516001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3782-4700","authenticated-orcid":true,"given":"Laibao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0218-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.05.29"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26848"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6935147"},{"issue":"26","key":"5","doi-asserted-by":"crossref","first-page":"19133","DOI":"10.1074\/jbc.M701917200","article-title":"Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion","volume":"282","author":"E. 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