{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:02:06Z","timestamp":1787061726689,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903629"],"award-info":[{"award-number":["81903629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    This study assessed the anti\u2010arthritic effect and protection of Gedunin (GDN) on joint tissues and revealed the possible mechanism in suppressing rheumatoid arthritis (RA).\n                    <jats:italic>Methods.<\/jats:italic>\n                    LPS\u2010induced macrophages and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010stimulated synovial fibroblasts (MH7A) or IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010stimulated primary rheumatoid arthritis synovial fibroblasts (RASFs) were used to evaluate the antiinflammatory effect of GDN. In addition, CIA\u2010induced arthritis was employed here to evaluate the anti\u2010arthritic effect. MTT and BRDU assays were utilized to evaluate the cell viability and proliferation, Q\u2010PCR was conducted to detect the mRNA expression of cytokines, FACS was adopted to monitor ROS production, while western blotting (WB) and siRNA interference were applied in confirming the anti\u2010arthritic effects of GDN\n                    <jats:italic>via<\/jats:italic>\n                    the Nrf2 signaling.\n                    <jats:italic>Results. In vitro<\/jats:italic>\n                    , cell viability was inhibited in macrophages and MH7A cells, but not in RASFs; but the proliferation of RASFs was significantly suppressed in time\u2010 and dose\u2010dependent manners. GDN suppressed cytokine levels in LPS\u2010stimulated macrophages and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010stimulated MH7A cells or RASFs. GDN suppressed ROS expression. Furthermore, GDN treatment notably dose\u2010dependently decreased the mRNA and protein expression of iNOS in LPS\u2010induced macrophages. sip62 interference results showed that GDN cause the less expression of HO\u20101 and Keap1 and also fail to inhibit cytokines after sip62 interference.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , GDN effectively inhibited paw swelling, arthritis score, and arthritis incidence and cytokines.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    Our study suggested that GDN exhibited strong antagonistic effect on arthritis both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo via<\/jats:italic>\n                    activation of Nrf2 signaling. Our work will provide a promising therapeutic strategy for RA.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6277760","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T23:50:10Z","timestamp":1649375410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["[Retracted] Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2\/ARE Signaling"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jian-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Kun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Chan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Xing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Jin-Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-4499","authenticated-orcid":false,"given":"Yan-Fang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-5967","authenticated-orcid":false,"given":"Xue-Qin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-1087","authenticated-orcid":false,"given":"Ming-Qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.07.004"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel065"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2050"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.159"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.003255"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400104"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705231"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.006"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.132720"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.09.007"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/238321"},{"key":"e_1_2_10_14_2","unstructured":"MJA. 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