{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:17:45Z","timestamp":1788905865896,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":174,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Diabetic foot ulcers (DFU) are among the serious complications which are closely linked to diabetes mellitus. However, there is still a lack of accurate and effective standard prevention and treatment programs for DFU. In this manuscript, we have investigated the function of lncRNA cancer susceptibility candidate 2 (CASC2)\/miR\u2010155\/hypoxia\u2010inducible factor 1\u2010alpha (HIF\u20101<jats:italic>\u03b1<\/jats:italic>) in the wound healing of DFU. We have analyzed lncRNA CASC2`s expression in the marginal tissues of ulcers in patients and mice with DFU. Additionally, the interaction relationship and mechanism between lncRNA CASC2, miR\u2010155, and HIF\u20101<jats:italic>\u03b1<\/jats:italic> were determined, which proved the effects of lncRNA CASC2\/miR\u2010155\/HIF\u20101<jats:italic>\u03b1<\/jats:italic> on fibroblasts apoptosis, proliferation, and migration. According to our study, the lncRNA CASC2\u2019s expression was low in the tissues of ulcers of DFU mice and patients. lncRNA CASC2\u2019s overexpression promoted fibroblasts migration, proliferation, and inhibited apoptosis and was beneficial for the healing of wounds, preferably in the DFU mice. In addition, lncRNA CASC2 directly targets miR\u2010155 and HIF\u20101<jats:italic>\u03b1<\/jats:italic> functions as miR\u2010155\u2019s target gene. Overexpression of miR\u2010155 abrogated the function of lncRNA CASC2. Similarly, HIF\u20101<jats:italic>\u03b1<\/jats:italic>\u2019s inhibition has reversed the effect of miR\u2010155 downregulation on fibroblasts. In general, overexpression of lncRNA CASC2 facilitated wound healing through miR\u2010155\/HIF\u20101<jats:italic>\u03b1<\/jats:italic> in DFU.<\/jats:p>","DOI":"10.1155\/2022\/6291497","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T19:20:15Z","timestamp":1656098415000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long Noncoding RNA CASC2 Facilitated Wound Healing through miRNA\u2010155\/HIF\u20101<i>\u03b1<\/i> in Diabetic Foot Ulcers"],"prefix":"10.1155","volume":"2022","author":[{"given":"Minjie","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-1237","authenticated-orcid":false,"given":"Shaoyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7119779"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2019.02.001"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.11.060"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.01.023"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12381"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27587"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20015"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1843498"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00574-8"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0629-9958"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12986"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2015.08.007"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32483"},{"key":"e_1_2_9_14_2","first-page":"494","article-title":"Long non-coding RNA CASC2 suppresses pancreatic cancer cell growth and progression by regulating the miR-24\/MUC6 axis","volume":"56","author":"Xu D. F.","year":"2020","journal-title":"International Journal of Oncology"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000508078"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11495"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.03.012"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42309-4"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2742"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq045"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0829"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-018-9778-z"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103555"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35316"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2018.23.sup9.s16"},{"key":"e_1_2_9_27_2","first-page":"1797","article-title":"lncRNA CASC2\/miR-18a-5p axis regulates the malignant potential of nasopharyngeal carcinoma by targeting RBBP8","volume":"41","author":"Miao W. J.","year":"2019","journal-title":"Oncology Reports"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.3727\/096504018x15178740729367"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26479"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202001_20063"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201903_17270"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101773"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12468"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2014_032"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534734617706636"},{"key":"e_1_2_9_36_2","first-page":"1939","article-title":"[The molecular mechanism of LncRNA-CASC2\/miR-155-5p\/APC Axis regulating the progression of non-hodgkin lymphoma]","volume":"28","author":"Zheng C. J.","year":"2020","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4518"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.592833"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.06.143"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12570"}],"container-title":["Contrast Media &amp; Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2022\/6291497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmi\/2022\/6291497.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/6291497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T07:08:39Z","timestamp":1721804919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/6291497"}},"subtitle":[],"editor":[{"given":"Yuvaraja","family":"Teekaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/6291497"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6291497","archive":["Portico"],"relation":{},"ISSN":["1555-4309","1555-4317"],"issn-type":[{"value":"1555-4309","type":"print"},{"value":"1555-4317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6291497"}}