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IBD includes two idiopathic disorders: Crohn\u2019s disease (CD) and ulcerative colitis (UC). In particular, UC causes inflammation and ulceration of the colon and rectum. There is no cure for UC. The pharmacological treatment is aimed at controlling and\/or reducing the inflammatory process and promoting disease remission. The present study investigated the possible protective effects of soluble dietary fiber (SDF) isolated from yellow passion fruit peel in the dextran sulfate sodium\u2010 (DSS\u2010) induced colitis model in mice, induced by 5% of DSS. The animals were treated with SDF (10, 30, or 100\u2009mg\/kg (po)), and the disease activity index was monitored. Colon tissues were collected, measured, and prepared for oxidative stress, inflammation, and histology analysis. SDF improved body weight loss, colon length, and disease activity index and prevented colonic oxidative stress by regulating GSH levels and SOD activity. Furthermore, SDF reduced colonic MPO activity, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and IL\u20101<jats:italic>\u03b2<\/jats:italic> levels and increased IL\u201010 and IL\u20106 levels. As observed by histological analysis, SDF treatment preserved the colonic tissue, the mucus barrier, and reduced inflammatory cell infiltration. Although this is a preliminary study, taken together, our data indicate that SDF may improve the course of DSS\u2010UC. More studies are needed to explore and understand how SDF promotes this protection.<\/jats:p>","DOI":"10.1155\/2022\/6298662","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T19:05:16Z","timestamp":1665860716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Protective Effect of Dietary Polysaccharides from Yellow Passion Fruit Peel on DSS\u2010Induced Colitis in Mice"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-3200","authenticated-orcid":false,"given":"Laryssa Regis","family":"Bueno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-6599","authenticated-orcid":false,"given":"Bruna","family":"da Silva 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