{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:22:43Z","timestamp":1784128963884,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Jishuitan Hospital","award":["ZR-201927"],"award-info":[{"award-number":["ZR-201927"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To explore the regulation of endogenous sulfur dioxide on oxidative stress in lung injury induced by sepsis. <jats:italic>Method<\/jats:italic>. Forty male Sprague Dawley rats were divided into control, sepsis, sepsis + SO<jats:sub>2<\/jats:sub>, and SO<jats:sub>2<\/jats:sub> group randomly used to observe survival rate. The other group of twenty\u2010eight rats were randomly divided as the same manner for mechanism research. The number of WBCS and the percentage of PMN cells were calculated. The microphotographs of morphological changes and the index of quantitative assessment (IQA) of lung tissues were calculated. The ratio of wet\/dry (W\/D) of lung tissues was calculated. Levels of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, MDA, NO, MPO, SOD, GSH\u2010px, and TNF\u2010<jats:italic>\u03b1<\/jats:italic> in plasma and lung tissues were measured. <jats:italic>Result<\/jats:italic>. The number of WBCS and the percentage of PMN cells decreased in sepsis (<jats:italic>p<\/jats:italic> all &lt; 0.05), and rebound in sepsis+SO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic> all &lt; 0.05). The IQA and W\/D of lung tissues increased in sepsis (<jats:italic>p<\/jats:italic> for <jats:italic>W<\/jats:italic>\/<jats:italic>D<\/jats:italic> &lt; 0.05), and decreased in sepsis+SO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic> all &lt; 0.05). H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and MDA of plasma and lung tissues increased in sepsis (<jats:italic>p<\/jats:italic> all &lt; 0.05) and rebound in sepsis+SO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic> for H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> of plasma and lung tissues &lt;0.05). NO and MPO of plasma and lung tissues increased in sepsis (<jats:italic>p<\/jats:italic> for NO and MPO of lung tissues &lt;0.05) and rebound in sepsis+SO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009all &lt; 0.05). SOD of plasma and lung tissues in sepsis group decreased (<jats:italic>p<\/jats:italic> all &lt;0.05) and increased in sepsis+SO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic> all &lt; 0.05). GSH\u2010px of plasma and lung tissues decreased in sepsis (<jats:italic>p<\/jats:italic> for plasma &lt;0.05) and increased in sepsis+SO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic> for GSH\u2010px of lung tissues &lt;0.05). TNF\u2010<jats:italic>\u03b1<\/jats:italic> of plasma and lung tissues increased in sepsis (<jats:italic>p<\/jats:italic> all&lt;0.05) and decreased in sepsis+SO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic> for lung tissue &lt;0.05). <jats:italic>Conclusion<\/jats:italic>. Endogenous sulfur dioxide improves the survival rate of sepsis by improving the oxidative stress response during lung injury.<\/jats:p>","DOI":"10.1155\/2022\/6339355","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T23:35:12Z","timestamp":1646004912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Endogenous Sulfur Dioxide Improves the Survival Rate of Sepsis by Improving the Oxidative Stress Response during Lung Injury"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-3988","authenticated-orcid":false,"given":"Zhiwei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-3930","authenticated-orcid":false,"given":"Jiaqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-0812","authenticated-orcid":false,"given":"Xin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3729-4271","authenticated-orcid":false,"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-6680","authenticated-orcid":false,"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30696-2"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-0991-6_9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2019.89593"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.19723\/j.issn.1671-167X.2019.02.007"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9167-9_22"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000958"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000963"},{"key":"e_1_2_9_8_2","first-page":"57","article-title":"Protamine-induced acute lung injury and the protective effect of agents that increase cAMP","volume":"17","author":"Hsu K.","year":"1993","journal-title":"Proceedings of the National Science Council, Republic of China. 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