{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:06:34Z","timestamp":1767920794489,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To prospectively study the application effect of traditional Chinese medicine (TCM) anticancer decoction with basic chemotherapy and nursing intervention on oral cancer patients after surgery and the effect on tumor markers and immune function. <jats:italic>Methods<\/jats:italic>. Eighty\u2010four postoperative oral cancer patients in our hospital from May 2017 to February 2019 were selected and divided into observation group (42 cases) and control group (42 cases). The control group was treated with basic chemotherapy combined with basic nursing care, and the observation group was treated with TCM anticancer decoction and comprehensive nursing intervention on the basis of the control group. The clinical efficacy, the occurrence of adverse reactions, the satisfaction of nursing care, and the two\u2010year cumulative survival rate of the two groups were compared. The immune function, tumor marker level, VAS score, QoR40 score, and survival quality score of the two groups were compared before and after nursing care. <jats:italic>Results<\/jats:italic>. The total clinical treatment efficiency of the observation group (88.10%) was significantly higher than that of the control group (69.05%), and the differences between the two groups in oral cleanliness, aspiration frequency, and oral comfort were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.05). The differences in the occurrence of halitosis, oral fungal infection, leukopenia, gastrointestinal reaction, and fever in the observation group were statistically significant compared with the control group (<jats:italic>P<\/jats:italic> &lt; 0.05). The nursing satisfaction rate in the observation group (95.24%) was significantly higher than that in the control group (78.57%). The two\u2010year cumulative survival rate of the observation group (92.86%) was significantly higher than that of the control group (73.81%). After nursing care, CD4+, CD4+\/CD8+, VAS scores, QoR40 scores, and quality of survival scores in both groups all increased, and CD8+, CD56+, CEA level, NSE level, and CA19\u20109 level all decreased (all <jats:italic>P<\/jats:italic> &lt; 0.05). <jats:italic>Conclusion<\/jats:italic>. The clinical efficacy of TCM anticancer decoction with basic chemotherapy and nursing interventions in the treatment of postoperative oral cancer patients was remarkable, which could significantly improve patients\u2019 oral cleanliness and comfort, reduce the frequency of sputum aspiration, improve patients\u2019 immunity, reduce tumor marker levels, inhibit tumor activity, improve patients\u2019 nursing satisfaction, further improve patients\u2019 treatment compliance, reduce patients\u2019 pain level, improve patients\u2019 survival quality, and prolong patients\u2019 survival time with high safety. It could be used as a theoretical basis for subsequent clinical research.<\/jats:p>","DOI":"10.1155\/2022\/6341381","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T01:20:05Z","timestamp":1648689605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Traditional Chinese Medicine Anticancer Decoction Combined with Basic Chemotherapy and Nursing Intervention on Oral Cancer Patients after Surgery and Its Effect on Tumor Markers and Immune Function"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-1669","authenticated-orcid":false,"given":"Dan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-482X","authenticated-orcid":false,"given":"Fengying","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4054-8188","authenticated-orcid":false,"given":"Lihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-2151","authenticated-orcid":false,"given":"Zhen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-3420","authenticated-orcid":false,"given":"Chengwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2015.03.006"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2014.999570"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000499"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.186696"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319839822"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-2063-y"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00870"},{"key":"e_1_2_7_8_2","first-page":"e15","article-title":"Protocols for management of oral complications of chemotherapy and\/or radiotherapy for oral cancer: systematic review and meta-analysis current","volume":"22","author":"Carneiro-Neto J. 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