{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:08:44Z","timestamp":1790960924120,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":188,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    ) is one of the leading causes of community\u2010acquired pneumonia in children and is also implicated in a variety of reactive extrapulmonary diseases. Recurrent and\/or severe respiratory infections are one of the most frequent manifestations of several types of primary immunodeficiency. Here, we reviewed the medical literature to assess the potential relevance of\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    in the infections observed in children affected with combined, humoral, and innate primary immune deficiencies.\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    does not result to be epidemiologically prevalent as a cause of pneumonia in children affected by primary immunodeficiencies, but this infection can have a persistent or severe course in this category of patients. Indeed, the active search of\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    could be useful and appropriate especially in children with humoral immune deficiencies. Indeed, most cases of\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    infection in primary immunodeficiencies are described in patients affected by a\/hypo\u2010gammaglobulinemia.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6343818","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T13:50:29Z","timestamp":1657288229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["<i>Mycoplasma pneumoniae<\/i>\n                    Infections and Primary Immune Deficiencies"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-9334","authenticated-orcid":false,"given":"Dimitri","family":"Poddighe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-1789","authenticated-orcid":false,"given":"Erkan","family":"Demirkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-4694","authenticated-orcid":false,"given":"Vitaliy","family":"Sazonov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micol","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.17.4.697-728.2004"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2018-0016"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.01.022"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000000494"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00023"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-220749"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2018.09.009"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2019.04.011"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000024894"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01806-13"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2016.6395"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12439"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.18502\/ijaai.v17i5.307"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22887"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00737-x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0290-5"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.04.049"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.619146"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e31825f95b9"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01248-12"},{"key":"e_1_2_9_21_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s12098-010-0313-9","article-title":"Prevalence of mycoplasma pneumoniae among HIV infected children","volume":"78","author":"Nadagir S. 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