{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:20:34Z","timestamp":1787242834937,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2019QL011"],"award-info":[{"award-number":["2019QL011"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MH120"],"award-info":[{"award-number":["ZR2019MH120"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . Glucocorticoid\u2010induced osteonecrosis of the femoral head is one of the most common causes of nontraumatic osteonecrosis of the femoral head, but its exact pathogenesis remains unclear. The aim of this study was to investigate the role of SIRT6 in the maintenance of bone tissue morphology and structure, intravascular lipid metabolism, and its potential molecular mechanism in glucocorticoid\u2010induced osteonecrosis of the femoral head.\n                    <jats:italic>Methods<\/jats:italic>\n                    . SIRT6 adenovirus was transfected into GIONFH in rats. The microstructure of rat bone was observed by micro\u2010CT and histological staining, and the expression of bone formation\u2010related proteins and angiogenesis\u2010related factors was determined through western blot and immunohistochemistry. Alkaline phosphatase activity, alizarin red staining, and the expression levels of Runx2 and osteocalcin were used to evaluate the osteogenic potential. And\n                    <jats:italic>in vitro<\/jats:italic>\n                    tube formation assay and immunofluorescence were used to detect the ability of endothelial cell angiogenesis.\n                    <jats:italic>Results<\/jats:italic>\n                    . Dexamethasone significantly inhibited osteoblast differentiation, affected bone formation, and destroyed microvessel formation, increased the intracellular Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and ROS levels and induced the occurrence of ferroptosis. SIRT6 can inhibit ferroptosis and restore the ability of bone formation and angiogenesis.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . SIRT6 can inhibit the occurrence of ferroptosis, reduce the damage of vascular endothelium, and promote osteogenic differentiation, so as to prevent the occurrence of osteonecrosis of the femoral head.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6360133","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T19:05:20Z","timestamp":1665687920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["SIRT6 Prevents Glucocorticoid\u2010Induced Osteonecrosis of the Femoral Head in 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