{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:58:42Z","timestamp":1776952722666,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Department of Guizhou Province","award":["3054"],"award-info":[{"award-number":["3054"]}]},{"name":"Science and Technology Department of Guizhou Province","award":["111"],"award-info":[{"award-number":["111"]}]},{"name":"Zunhua Kehua Tech","award":["3054"],"award-info":[{"award-number":["3054"]}]},{"name":"Zunhua Kehua Tech","award":["111"],"award-info":[{"award-number":["111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,9,26]]},"abstract":"<jats:p>Objective. To investigate the effects of Compaximab and raizumab on retinal function and serum interleukin-17A level in retinopathy of prematurity. Methods. Sixty cases of retinopathy of prematurity treated in our hospital from February 2019 to April 2021 were selected. The patients were randomly divided into control group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>30<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and research group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>30<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The control group was treated with Compaq and the research group was treated with razumab. The curative effect, retinal function, incidence of complications, intraocular pressure at different time, and the level of serum interleukin-17A were compared. Results. Compared with the two groups, the curative effect of the research group 93.33% (28\/30) was greater than that of the control group 66.67% (20\/30), and the difference was statistically significant (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Compared with the incidence of complications, the incidence of corneal opacity, lens opacity, preretinal and vitreous hemorrhage, endophthalmitis, and traction retinal detachment in the research group was greatly lower, and the difference was statistically significant (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Following the therapy, the IOP of the two groups decreased at different times. The IOP of 1\u2009min, 10\u2009min, and 30\u2009min in the research group was obviously lower, and the difference was statistically significant (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Following treatments, the levels of serum IL-17A were decreased. Compared with the control group, the level of serum IL-17A in the research group was greatly downregulated, and the difference was statistically significant (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Conclusion. Intravitreal injection of razumab is an effective treatment for retinopathy of prematurity, which can effectively improve the retinal function of infants. The level of serum interleukin-17A can be reduced and intraocular pressure can be regulated, which is safe and effective.<\/jats:p>","DOI":"10.1155\/2022\/6371994","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T02:50:18Z","timestamp":1664247018000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy"],"prefix":"10.1155","volume":"2022","author":[{"given":"Huixuan","family":"Ren","sequence":"first","affiliation":[{"name":"Ophthalmology, Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University, Guizhou Provincial Eye Hospital, Guizhou Branch Center of National Clinical Research Center for Eye Diseases, Guizhou Provincial Key Laboratory of Characteristic Eye Diseases Characteristics, Zunyi, Guizhou 563003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Su","sequence":"additional","affiliation":[{"name":"Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunian","family":"Xu","sequence":"additional","affiliation":[{"name":"Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5900-9881","authenticated-orcid":true,"given":"Shanjun","family":"Cai","sequence":"additional","affiliation":[{"name":"Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"52","key":"1","first-page":"394","article-title":"Eye diseases and conditions-retinopathy of prematurity; recent studies from Stanford University add new data to retinopathy of prematurity (current management of retinopathy of prematurity in sub-saharan Africa)","volume":"31","year":"2020","journal-title":"Journal of Technology &amp; Science"},{"issue":"62","key":"2","first-page":"395","article-title":"Eye diseases and conditions-retinopathy of prematurity; new retinopathy of prematurity study findings have been reported by investigators at University of Ataturk (determination and comparison of the urinary iodine levels of premature infants with and without retinopathy of prematurity)","volume":"45","year":"2020","journal-title":"Chemicals &amp; Chemistry"},{"issue":"52","key":"3","first-page":"67","article-title":"Eye diseases and conditions-retinopathy of prematurity; findings in retinopathy of prematurity reported from Korea University (incidence, long-term visual outcomes, and mortality in retinopathy of prematurity in Korea: a nationwide population-based study)","volume":"45","year":"2020","journal-title":"Biotech Week"},{"issue":"53","key":"4","first-page":"494","article-title":"Eye diseases and conditions-retinopathy of prematurity; findings from Royal Children\u2019s Hospital update understanding of retinopathy of prematurity (anaesthesia management of laser photocoagulation for retinopathy of prematurity. 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