{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:03:34Z","timestamp":1770231814684,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070679"],"award-info":[{"award-number":["82070679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019GK5010"],"award-info":[{"award-number":["2019GK5010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022SK2040"],"award-info":[{"award-number":["2022SK2040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Province Science and Technology Grant","award":["82070679"],"award-info":[{"award-number":["82070679"]}]},{"name":"Hunan Province Science and Technology Grant","award":["2019GK5010"],"award-info":[{"award-number":["2019GK5010"]}]},{"name":"Hunan Province Science and Technology Grant","award":["2022SK2040"],"award-info":[{"award-number":["2022SK2040"]}]},{"name":"Hunan Provincial Key Research and Development Program","award":["82070679"],"award-info":[{"award-number":["82070679"]}]},{"name":"Hunan Provincial Key Research and Development Program","award":["2019GK5010"],"award-info":[{"award-number":["2019GK5010"]}]},{"name":"Hunan Provincial Key Research and Development Program","award":["2022SK2040"],"award-info":[{"award-number":["2022SK2040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022,5,10]]},"abstract":"<jats:p>Objectives. Factors prognostic of survival in liver transplant (LT) recipients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) remain unclear. This study evaluated risk factors for survival in LT recipients with HBV-ACLF and determined the scoring system optimal for assessing patient prognosis. Methods. This retrospective study included 323 HBV-ACLF related patients undergoing LT, including 112, 146, and 65 patients with HBV-ACLF grades 1, 2, and 3, respectively. Overall survival (OS) was estimated by the Kaplan\u2013Meier method, and factors associated with survival were analysed by multivariate Cox proportional hazards models. Pretransplant prognostic scoring systems were compared by receiver operating characteristic (ROC) curve analysis. Results. The one-year survival rate was significantly lower in HBV-ACLF grade 3 (80.0%) than in grades 1 (93.8%) and 2 (91.8%) recipients (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.0063<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Cox multivariate analysis showed that age &gt;53 years (hazard ratio (HR) 3.731; 95% confidence interval (CI) 1.640\u20138.407), WBC count &gt;8.6\u2009\u00d7\u2009109\/L (HR 4.544; 95% CI 1.140\u201318.107), HBV-ACLF 3 (HR 2.729; 95% CI 1.050\u20137.096), and cold ischaemia time &gt;8.5 hours (HR 2.867; 95% CI, 1.38\u20135.921) were independently prognostic of 1-year survival. Comparisons of pretransplant scoring systems showed that chronic liver failure-consortium ACLF score (CLIF-C ACLFs) was superior to COSSH-ACLF, MELD-Na, and MELD scores in predicting 1-year OS in these patients. Conclusions. Age &gt;53 years, WBC counts &gt;8.6\u2009\u00d7\u2009109\/L, HBV-ACLF grade 3, and cold ischaemia time &gt;8.5 hours are independently prognostic of OS in LT recipients with HBV-ACLF. CLIF-C ACLFs is superior to other scoring methods in predicting 1-year OS in these patients.<\/jats:p>","DOI":"10.1155\/2022\/6390809","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T22:05:07Z","timestamp":1652220307000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Factors Prognostic of Survival in Liver Transplant Recipients with Hepatitis B Virus Related Acute-on-Chronic Liver Failure"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-6838","authenticated-orcid":true,"given":"Zhengjun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Liver Transplant, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"},{"name":"Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"},{"name":"Transplant Medical Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"},{"name":"Transplant Medical Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangshun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"},{"name":"Transplant Medical Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongzhou","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"},{"name":"Transplant Medical Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-2403","authenticated-orcid":true,"given":"Jiequn","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"},{"name":"Transplant Medical Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.026"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314641"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.035"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(19)30342-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5108781"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-014-9580-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.189639"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15793"},{"key":"9","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.41","article-title":"Acute-on-chronic liver failure in cirrhosis","volume":"2","author":"V. 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