{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:24Z","timestamp":1792787604754,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":128,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Qingpu District Science and Technology Development Fund Medical and Health Project","award":["QKY2021-14"],"award-info":[{"award-number":["QKY2021-14"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To compare the clinical value of contrast\u2010enhanced ultrasound and conventional ultrasound\u2010guided puncture biopsy in peripulmonary lesions of different sizes.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . 110 patients with peripulmonary lesions were randomly divided into two groups: the conventional ultrasound\u2010guided group and the contrast\u2010enhanced ultrasound\u2010guided group. The lesions in the two groups were further divided into two groups according to the size of the lesions, and the tissues taken after puncture biopsy were sent for pathological examination. The pathological results were compared with the postoperative pathological results and other examination results, and the complications were recorded at the same time.\n                    <jats:italic>Results<\/jats:italic>\n                    . In the conventional ultrasound group, the success rate of single puncture was 72.7% and the success rate of puncture was 80.0%; in the contrast group, the success rate of single puncture was 90.9% and the success rate of puncture was 94.6%. The difference between the two groups was statistically significant. There was no significant difference in needle bleeding and pneumothorax between the two groups. In the &lt;30\u2009mm group, there was no significant difference in the success rate of single puncture and the success rate of puncture between the two groups according to the size of the lesions. In the \u226530\u2009mm group, the success rate of single puncture (97.1%) and puncture success rate (97.1%) in the contrast guidance group were higher than those in the conventional ultrasound guidance group (70.3%, 78.4%) and the difference was statistically significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Compared with conventional ultrasound, for peripheral pulmonary lesions guided by contrast\u2010enhanced ultrasonography, especially when the maximum diameter of the lesion is \u2265\u200930\u2009mm, needle biopsy has better guiding significance; for peripheral lung lesions with a maximum diameter of &lt;30\u2009mm, contrast\u2010enhanced ultrasonography is compared with conventional ultrasound guidance. The puncture success rate was not significantly different.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6425145","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T16:35:14Z","timestamp":1652114114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of the Value of Conventional Ultrasound and Contrast\u2010Enhanced Ultrasound\u2010Guided Puncture Biopsy in Different Sizes of Peripheral Pulmonary Lesions"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-8377","authenticated-orcid":false,"given":"Qi-Qin","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-6447","authenticated-orcid":false,"given":"Shi-Yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Li","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Sheng","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"404","article-title":"etc. Contrast analysis of contrast-enhanced ultrasonography and conventional ultrasound-guided puncture for peripheral pulmonary lesions","volume":"36","author":"Tang M.","year":"2020","journal-title":"Chinese Journal of Ultrasound in Medicine"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199710000-00005"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1557"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/531507"},{"key":"e_1_2_9_5_2","first-page":"274","article-title":"Application of contrast enhanced ultrasound combined biopsy in qualitative diagnosis of peripheraI pulmonary lesions","volume":"14","author":"Li Q.","year":"2017","journal-title":"Chinese Journal of Interventional Imaging and Therapy"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3894"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.01.029"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2014.06.010"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.01.025"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2014.161"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_115_18"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_208_17"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.2.r01fe33491"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.01.88"},{"key":"e_1_2_9_15_2","first-page":"596","article-title":"Endobronchial u1trasound with a guide sheath for small malignant pulmonary nodules: a retrospective comparison between central and peripheral locations","volume":"7","author":"Chavez C.","year":"2015","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.11.1479"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0096(199606)24:5<225::AID-JCU1>3.0.CO;2-G"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.05.0535"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-001-0123-6"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2005.10.008"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jus.2008.05.008"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.10.1403"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/531507"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.01.016"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/231782"},{"key":"e_1_2_9_26_2","first-page":"124","article-title":"The value of contrast-enhanced ultrasonography in differential diagnosis of peripheral lung cancer","volume":"21","author":"Chen B. 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