{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:32:42Z","timestamp":1740151962998,"version":"3.37.3"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81822049"],"award-info":[{"award-number":["81822049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2022,9,17]]},"abstract":"<jats:p>Background. Oral iron supplement is commonly prescribed to heart failure patients with iron deficiency. However, the effects of oral iron for heart failure remain controversial. This study included randomized controlled trials (RCTs) for meta-analysis to evaluate the effects of oral iron for heart failure patients. Methods. Nine databases (The Cochrane Library, Embase, PubMed, CINAHL, Web of science, CNKI, SinoMed, VIP, and Wanfang) were searched for RCTs of oral iron for heart failure from inception to October 2021. The effects were assessed with a meta-analysis using Revman 5.3 software. The trial sequential analysis was performed by TSA 0.9.5.10 beta software. The risk of bias of trials was evaluated via Risk of Bias tool. The evidence quality was assessed through GRADE tool. Results. Four studies including 582 patients with heart failure and iron deficiency were enrolled. The results indicated that oral iron treatment could improve left ventricular ejection fraction (LVEF, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>MD<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>1.52<\/a:mn>\n                        <a:mi>%<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI: 0.69 to 2.36, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.0003<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) and serum ferritin (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>MD<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>1.64<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, 95% CI: 0.26 to 3.02, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.02<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). However, there was no between-group difference in the 6-minute walk distances (6MWT), N terminal pro B type natriuretic peptide (NT-proBNP) or hemoglobin level when compared with control group. Subgroup analyses revealed that the effects of oral iron on 6 MWT and serum ferritin could not be affected by duration and frequency of oral iron uptakes. In trial sequential analysis of LVEF and serum ferritin, the Z-curves crossed the traditional boundary and trail sequential monitoring boundary but did not reach the required information size. Conclusion. This analysis showed that oral iron could improve cardiac function measured by LVEF, and iron stores measured serum ferritin, but lack of effect on exercise capacity measured by 6 MWT, and iron stores measured by hemoglobin. Given the overall poor methodological quality and evidence quality, these findings should be treated cautiously.<\/jats:p>","DOI":"10.1155\/2022\/6442122","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T18:50:09Z","timestamp":1663440609000},"page":"1-16","source":"Crossref","is-referenced-by-count":1,"title":["Effects and Safety of Oral Iron for Heart Failure with Iron Deficiency: A Systematic Review and Meta-Analysis with Trial Sequential Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-6196","authenticated-orcid":true,"given":"Nannan","family":"Tan","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"},{"name":"Beijing Key Laboratory of TCM Syndrome and Formula, Beijing, China"},{"name":"Key Laboratory of Beijing University of Chinese Medicine, Ministry of Education, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanjing Pukou Hospital of Traditional Chinese Medicine, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"},{"name":"Beijing Key Laboratory of TCM Syndrome and Formula, Beijing, China"},{"name":"Key Laboratory of Beijing University of Chinese Medicine, Ministry of Education, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"},{"name":"Beijing Key Laboratory of TCM Syndrome and Formula, Beijing, China"},{"name":"Key Laboratory of Beijing University of Chinese Medicine, Ministry of Education, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-7040","authenticated-orcid":true,"given":"Guanjing","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"},{"name":"Beijing Key Laboratory of TCM Syndrome and Formula, Beijing, China"},{"name":"Key Laboratory of Beijing University of Chinese Medicine, Ministry of Education, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchi","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"},{"name":"Beijing Key Laboratory of TCM Syndrome and Formula, Beijing, China"},{"name":"Key Laboratory of Beijing University of Chinese Medicine, Ministry of Education, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-0830","authenticated-orcid":true,"given":"Qiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of TCM Syndrome and Formula, Beijing, China"},{"name":"Key Laboratory of Beijing University of Chinese Medicine, Ministry of Education, China"},{"name":"School of Life Science, Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-9517","authenticated-orcid":true,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"},{"name":"Beijing Key Laboratory of TCM Syndrome and Formula, Beijing, China"},{"name":"Key Laboratory of Beijing University of Chinese Medicine, Ministry of Education, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1001\/jama.2020.13310"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1016\/S0140-6736(17)32520-5"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1007\/s00392-014-0788-x"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.cardfail.2017.09.014"},{"issue":"11","key":"5","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/ejhf.1629","article-title":"Prevalence of heart failure and left ventricular dysfunction in China: the China Hypertension Survey, 2012\u20132015","volume":"21","author":"G. 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