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Cisplatin chemotherapy is a principal treatment normally given to the prostate cancer patients. Nonetheless, on its own, cisplatin loses efficacy once administered due to liver pass effects and other biochemical attacks. In this paper, we looked at preparation of PCL nanoparticles loaded with cisplatin and their potential for the treatment of prostate cancer. PCL nanoparticles protect cisplatin from biochemical attack, thus increasing drug efficacy. Incorporation of P-glycoprotein inhibitors in PCL nanoparticles (NPs) loaded with cisplatin could improve prostate cancer treatment even more.<\/jats:p>","DOI":"10.1155\/2022\/6449607","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T23:35:09Z","timestamp":1657928109000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Preparation of PCL Electrospun Fibers Loaded with Cisplatin and Their Potential Application for the Treatment of Prostate Cancer"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-9279","authenticated-orcid":true,"given":"Hilla","family":"Mills","sequence":"first","affiliation":[{"name":"Department of Medical Science, University for Development, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Acquah","sequence":"additional","affiliation":[{"name":"Department of Medical Science, University for Development, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nova","family":"Tang","sequence":"additional","affiliation":[{"name":"RD Lab, The Hospital Institute for Hebal Research, 50200 Toluca, Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2723-5910","authenticated-orcid":true,"given":"Luke","family":"Cheung","sequence":"additional","affiliation":[{"name":"RD Lab, The Hospital Institute for Hebal Research, 50200 Toluca, Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Klenk","sequence":"additional","affiliation":[{"name":"Research Institution of Clinical Biomedicine, Hospital University Medical Centre, 89000 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-5718","authenticated-orcid":true,"given":"Ronald","family":"Glassen","sequence":"additional","affiliation":[{"name":"Research Institution of Clinical Biomedicine, Hospital University Medical Centre, 89000 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Pirson","sequence":"additional","affiliation":[{"name":"Industrial Research Group, International College of Science and Technology, Route de Lennik 800, CP 590, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1012-7331","authenticated-orcid":true,"given":"Alain","family":"Albert","sequence":"additional","affiliation":[{"name":"Industrial Research Group, International College of Science and Technology, Route de Lennik 800, CP 590, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong Trinh","family":"Hoang","sequence":"additional","affiliation":[{"name":"Clinical Analysis Lab, Center of Bio-Medicine, Hanoi, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-0011","authenticated-orcid":true,"given":"Thang Nguyen","family":"Van","sequence":"additional","affiliation":[{"name":"Clinical Analysis Lab, Center of Bio-Medicine, Hanoi, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"5191","key":"1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/222385a0","article-title":"Platinum compounds: a new class of potent antitumour agents","volume":"222","author":"B. 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