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Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic \u03b2-cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.<\/jats:p>","DOI":"10.1155\/2022\/6453882","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T01:35:19Z","timestamp":1657157719000},"page":"1-16","source":"Crossref","is-referenced-by-count":34,"title":["Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-2605","authenticated-orcid":true,"given":"Nurulmuna","family":"Mohd Ghozali","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 59100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1263-103X","authenticated-orcid":true,"given":"Nelli","family":"Giribabu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 59100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-0490","authenticated-orcid":true,"given":"Naguib","family":"Salleh","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 59100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101498"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297918110056"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1017\/s0029665117000349"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.02.002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.000620"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1017\/s1368980011000565"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.12.016"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00910"},{"issue":"3","key":"9","first-page":"243","article-title":"Indications on the use of vitamin D and vitamin D metabolites in clinical phenotypes","volume":"7","author":"M. 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