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Recent studies found that long-term noise exposure can change synaptic and firing properties in the central auditory system, which will be detected by the acoustic startle reflex. However, the perceptual consequences of long-term low-intensity sound exposure are indistinct. This study will detect the effects of moderate-level noise exposure (83\u2009dB SPL) on auditory loudness, and temporal processing was evaluated using CBA\/CaJ mice. C-Fos staining was used to detect neural activity changes in the central auditory pathway. With two weeks of 83\u2009dB SPL noise exposure (8 hours per day), no persistent threshold shift of the auditory brainstem response (ABR) was identified. On the other hand, noise exposure enhanced the acoustic startle response (ASR) and gap-induced prepulse inhibition significantly (gap-PPI). Low-level noise exposure, according to the findings, can alter temporal acuity. Noise exposure increased the number of c-Fos labeled neurons in the dorsal cochlear nucleus (DCN) and caudal pontine reticular nucleus (PnC) but not at a higher level in the central auditory nuclei. Our results suggested that noise stimulation can change acoustical temporal processing presumably by increasing the excitability of auditory brainstem neurons.<\/jats:p>","DOI":"10.1155\/2022\/6463355","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T02:20:09Z","timestamp":1669083609000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["Low Intensity Noise Exposure Enhanced Auditory Loudness and Temporal Processing by Increasing Excitability of DCN"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-6564","authenticated-orcid":true,"given":"Lin","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, The First Hospital of Dalian Medical University, Dalian, China"},{"name":"Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7515-3595","authenticated-orcid":true,"given":"Katie","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1793-6748","authenticated-orcid":true,"given":"Haolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Hospital of Dalian Medical University, Dalian, China"},{"name":"Department of General Surgery, The First Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-4238","authenticated-orcid":true,"given":"Matthew A.","family":"Xu-Friedman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-6161","authenticated-orcid":true,"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12759"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00139.2003"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2226-04.2005"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)66001-4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-014-2979-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.03.004"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3026749"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.11.028"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.08.009"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-007-0098-3"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.12.024"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00098-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100794"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.11.018"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.105.1.33"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.1.188"},{"issue":"2","key":"17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0006-8993(91)90819-H","article-title":"Neuronal activity and tonotopy in the auditory system visualized by c-Fos gene expression","volume":"567","author":"G. 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