{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:35:08Z","timestamp":1768005308074,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Overactive bladder (OAB) is characterized by urgency and frequency with (OAB wet) or without (OAB dry) urge urinary incontinence (UUI). In the phase 3 EMPOWUR trial, vibegron\u2014a selective <jats:italic>\u03b2<\/jats:italic><jats:sub>3<\/jats:sub>\u2010adrenergic receptor agonist for the treatment of OAB\u2014significantly improved daily number of urgency episodes and micturitions vs. placebo (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). These post hoc analyses aimed to compare the efficacy of vibegron vs. placebo in OAB dry and wet populations. <jats:italic>Methods<\/jats:italic>. Patients were randomly assigned 5:5:4 to receive once\u2010daily vibegron 75\u2009mg, placebo, or tolterodine 4\u2009mg extended release, respectively, for 12\u2009weeks. Baseline criteria for OAB dry included an average of \u22658 micturitions, \u22653 urgency episodes, and &lt;1 UUI episode per diary day and for OAB wet included an average of \u22658 micturitions and \u22651 UUI episode per diary day. Change from baseline in mean daily number of urgency episodes and micturitions was assessed in both populations. <jats:italic>Results<\/jats:italic>. Of the 1463 patients included in the full analysis set, 336 (23%) had OAB dry (vibegron, <jats:italic>N<\/jats:italic>\u2009=\u2009123; placebo, <jats:italic>N<\/jats:italic>\u2009=\u2009115; and tolterodine, <jats:italic>N<\/jats:italic>\u2009=\u200998), and 1127 (77%) had OAB wet (vibegron, <jats:italic>N<\/jats:italic>\u2009=\u2009403; placebo, <jats:italic>N<\/jats:italic>\u2009=\u2009405; and tolterodine, <jats:italic>N<\/jats:italic>\u2009=\u2009319). Vibegron was associated with significant reductions (95% CIs of the least squares mean differences [LSMD] does not include 0) from baseline at week 12 vs. placebo in mean daily urgency episodes for the dry (LSMD [95% CI], \u20121.0 [\u20122.0, \u20120.1]) and wet (\u20120.6 [\u20121.0, \u20120.1]) populations. Vibegron was associated with significant reductions from baseline at week 12 vs. placebo in mean daily micturitions for the dry (LSMD [95% CI], \u20120.8 [\u20121.5, \u2012 0.1]) and wet (\u20120.5 [\u20120.8, \u20120.1]) populations. There were no significant differences in either outcome between tolterodine and placebo for either the dry or wet populations in this study. <jats:italic>Conclusions<\/jats:italic>. In this subgroup analysis from the EMPOWUR trial, vibegron was associated with significant reductions compared with placebo in urgency episodes and micturitions in both the OAB dry and wet populations, suggesting that vibegron is similarly efficacious for these endpoints in patients with and without UUI. This trial is registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03492281\">NCT03492281<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2022\/6475014","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T16:50:09Z","timestamp":1649868609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vibegron for the Treatment of Patients with Dry and Wet Overactive Bladder: A Subgroup Analysis from the EMPOWUR Trial"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-765X","authenticated-orcid":false,"given":"David","family":"Staskin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-9015","authenticated-orcid":false,"given":"Jeffrey","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susann","family":"Varano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-506X","authenticated-orcid":false,"given":"Michael","family":"Kennelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane K.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt T.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise D.","family":"Shortino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael A.","family":"Jankowich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N.","family":"Mudd Jr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Diagnosis and Treatment of Overactive Bladder (Non-neurogenic) in Adults: AUA\/SUFU Guideline","author":"Gormley E. 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