{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:49:32Z","timestamp":1787161772639,"version":"build-2736575974"},"reference-count":151,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Growing concern for public health has increased the need to change the paradigm towards a healthcare system that advocates holistic practices while reducing adverse effects. Herbal therapy is becoming an integral part of the therapeutic arsenal, and several successful plant\u2010derived compounds\/molecules are being introduced into the market. The medicinal plants belonging to the genus\n                    <jats:italic>Thymus<\/jats:italic>\n                    are among the most important species within the Lamiaceae family. One of them is\n                    <jats:italic>Thymus algeriensis<\/jats:italic>\n                    which is mainly distributed in the Mediterranean region. For a long time, this species has been used in traditional medicine to treat several disorders and diseases including inflammation, diabetes, rheumatism, digestive, and respiratory affections. This review describes the traditional uses, phytochemical composition, and biological and pharmacological activities of\n                    <jats:italic>T. algeriensis<\/jats:italic>\n                    extracts. Data were obtained using electronic databases such as SciFinder\n                    <jats:sup>n<\/jats:sup>\n                    , ScienceDirect, Scopus, and Web of Science. Several plant\u2010based extracts and a broad spectrum of identified secondary metabolites were highlighted and discussed with respective activities and modes of action.\n                    <jats:italic>T. algeriensis<\/jats:italic>\n                    represents a promising natural resource for the pharmaceutical industry mainly for antioxidant, anti\u2010inflammatory, antimicrobial, and anticancer activities. Considering these findings, more research is needed to transmute the conventional uses of\n                    <jats:italic>T. algeriensis<\/jats:italic>\n                    into scientifically sound information. Moreover, extensive preclinical, clinical, toxicological, and pharmacokinetic trials on this species and its derivatives compounds are required to underpin the mechanisms of action and ensure its biosafety and efficiency. This comprehensive review provides a scientific basis for future investigations on the use of\n                    <jats:italic>T. algeriensis<\/jats:italic>\n                    and derived compounds in health maintenance and promotion and disease prevention.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6487430","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T17:05:08Z","timestamp":1653498308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of\n                    <i>Thymus algeriensis<\/i>\n                    Boiss. &amp; Reut"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-941X","authenticated-orcid":false,"given":"Ismail","family":"Mahdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-8833","authenticated-orcid":false,"given":"Widad Ben","family":"Bakrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-451X","authenticated-orcid":false,"given":"Gabin Thierry M.","family":"Bitchagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-2488","authenticated-orcid":false,"given":"Hassan","family":"Annaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-2066","authenticated-orcid":false,"given":"Mona F.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2719-8534","authenticated-orcid":false,"given":"Mansour","family":"Sobeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.06.001"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2010.04.008"},{"key":"e_1_2_13_3_2","first-page":"132","article-title":"Marketing trends & future prospects of herbal medicine in the treatment of various disease","volume":"4","author":"Gunjan M.","year":"2015","journal-title":"World Journal of Pharmaceutical Research"},{"key":"e_1_2_13_4_2","first-page":"75","volume-title":"Advances in Food and Nutrition Research","author":"\u0160krov\u00e1nkov\u00e1 S.","year":"2012"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/146832"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2017-13714"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2018.08.041"},{"key":"e_1_2_13_8_2","volume-title":"Flore de Tunisie","author":"Le Floc'h E.","year":"2008"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900248"},{"key":"e_1_2_13_10_2","volume-title":"Studies on the genus","author":"Morales R.","year":"1996"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.4324\/9780203216859"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.03.021"},{"key":"e_1_2_13_13_2","volume-title":"Flore et \u00c9cosyst\u00e8mes Du Maroc: Evaluation et Pr\u00e9servation De La Biodiversit\u00e9","author":"Benabid A.","year":"2000"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2019.09.004"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-28"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/11263504.2012.761290"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.14233\/ajchem.2019.21805"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020463"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201019666180817141512"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-13-138"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8110515"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10040599"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2556-y"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109500"},{"key":"e_1_2_13_25_2","first-page":"133","article-title":"Terpenoid content of the leaves of Thymus algeriensis Boiss","volume":"24","author":"Gedara S. 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